Objectives − The aim of our article is to highlight the adverse effects midazolam, which causes abnormal behavior and a paradoxical behavioral reaction, although it used for sedation seizure control, as well preoperative procedure-related in neonates.Case Presentation We report myoclonic seizure-like activity four preterm neonates, who received intravenous midazolam before laser photocoagulatio...

Oromucosal midazolam (Buccolam™) is a benzodiazepine approved for the treatment of pediatric patients with acute, prolonged, convulsive seizures. This article reviews the pharmacologic properties of oromucosal midazolam and its clinical efficacy and tolerability for the treatment of prolonged acute convulsive seizures in pediatric patients aged 3 months to <18 years. Midazolam exerts its action...

We compared the efficacy of intranasal midazolam, ketamine and their mixture as premedication in children with tetralogy of Fallot (TOF) using bispectral index (BIS), sedation score and separation score at the time of separation from parent. Sedation score at the time of intravenous cannulation was also measured. Children with TOF physiology were randomly divided into three equal groups of 20 e...

Background. The aim of this study was to investigate the clinical efficacy and potential side effects of sublingual midazolam, used for premedication, in comparison with intravenous midazolam. The second aim was to explore cost-effectiveness of sublingual midazolam administration. Methods. A prospective, randomized, controlled, single-blinded trial was conducted at the Clinical Hospital Centre ...

OBJECTIVE The purpose of the present study is to compare efficacy and safety of buccal midazolam with intravenous diazepam in control of seizures in Iranian children. METHODS This is a randomized clinical trial. 92 patients with acute seizures, ranging from 6 months to 14 years were randomly assigned to receive either buccal midazolam (32 cases) or intravenous diazepam (60 cases) at the emerg...

Intranasal administration of midazolam has been of particular interest because of the rapid and reliable onset of action, predictable effects, and avoidance of injections. The available intravenous formulation (Dormicum i.v. solution from Hoffmann-La Roche) is however less than optimal for intranasal administration due to low midazolam concentration and acidity of the formulation (pH 3.0-3.3). ...

objecive prolonged and uncontrolled refractory status epilepticus (se) is a life-threatening medical emergency in children (1,2,3). there is no consensus on the optimal therapy for refractory status epilepticus (1). the aim of this study was to develop a new method for treating patients with refractory status epilepticus. materials & methods ten children with refractory status epilepticus in mo...

Intravenous sedation is effective to reduce fear and anxiety in dental treatment. It also has been used for behavior modification technique in dental patients with special needs. Midazolam and propofol are commonly used for intravenous sedation. Although there have been many researches on the effects of midazolam and propofol on vital function and the recovery profile, little is known about mus...

introduction: endoscopy is an invasive and painful procedure in children. since children can not tolerate pain and stress, sedation is necessary in pediatric endoscopy. the aim of this study was comparison of propofol versus intravenous midazolam for reducing anxiety in children.   materials and methods: in this study, 103 patients (2-14 years old) in whom endoscopy was indicated were divided i...