Purpose: We evaluate the results and complications of our intraventricular fibrinolysis protocol. Material and methods: A retrospective analysis was made of the cases of intraventricular hemorrhage with 13-bed Intensive Care Unit. Graeb score 6 or above subjected to intraventricular fibrinolysis. We gathered demographic parameters, clinical risk scores, tomography data and case histories showin...

We present a 71-year old woman treated with 14 days of 5 mg intraventricular caspofungin for Scedosporium apiospermum complex meningoencephalitis diagnosed after spinal fusion and instrumentation. Cerebrospinal fluid studies improved during therapy and intraventricular administration was well tolerated. Within weeks of discontinuation, the patient experienced clinical deterioration with disease...

Twenty five of 106 preterm infants of 34 weeks' gestation or less developed intraventricular haemorrhage within the first 48 hours of life. A comparison of infants with and without intraventricular haemorrhage showed no significant differences in their haemostatic parameters at birth. At age 48 hours the group with intraventricular haemorrhage showed a prolonged activated partial thromboplastin...

background:intraventricular hemorrhage is the most common intracranial hemorrhage in premature infants. the objective of this study was to investigate the relationship between intraventricular hemorrhage and blood leukocyte count. materials and methods:this was a cross-sectional simple sampling study conducted from the beginning of 2006 to 2010 in ali-asghar children’s hospital. inclusion crite...

germinal matrix-intraventricular hemorrhage (ivh) is the most common variety of neonatal intracranial hemorrhage and is characteristics of the premature infant. the importance of the lesion relates not only to its high incidence but to their attendant complications (ic: hydrocephalus). brain sonography is the procedure of choice in diagnosis of germinal matrix- intraventricular hemorrhage and h...

PURPOSE We evaluate the results and complications of our intraventricular fibrinolysis protocol. MATERIAL AND METHODS A retrospective analysis was made of the cases of intraventricular hemorrhage with 13-bed Intensive Care Unit. Graeb score 6 or above subjected to intraventricular fibrinolysis. We gathered demographic parameters, clinical risk scores, tomography data and case histories showin...

Purpose: To elucidate the mechanistic basis for efficacy of intrathecal rituximab. We evaluated complement activation as well as the pharmacokinetics of intraventricular rituximab in patients who participated in two phase 1 multicenter studies. ExperimentalDesign:Weevaluated complement activation as a candidatemediator of rituximabwithin the central nervous system (CNS). Complement C3 and C5b-9...