The use of radioactive iodine ((131)I) for the treatment of thyroid carcinoma has changed over the past 50 y. These changes are based on increasing awareness of the biophysical properties of (131)I and new discoveries concerning the biology of iodine handling by thyroid cells. The therapeutic administration of (131)I for thyroid remnant ablation and for metastases requires an appreciation of io...

A technic, efficient in use ~ of I TM, has been developed for introducing I TM into 4-mg. amounts of antibody or 3,-globulin protein at a level of 10 me. I ~al per mg. protein with a resulting iodine content of ~-S atoms per protein molecule of 160,000 molecular weight. Oak Ridge I TM was adjusted to pH 8 with borate buffer and the requisite amount of hydrochloric acid. To this solution was add...

Various radioisotopes have been used with some success to establish the presence and position of brain tumors. These have included phosphorous 32 (1); iodine 131; iodine 131 diiodofluorescein (2); iodine 131 serum proteins (3,4), and iodine 131 antiserum (5); potassium 42 (6); arsenic 72 and 74 (7,8); and copper 64 (9). In 1960, Blau and Bender reported that radiomercury labeled Neohydrin (chlo...

The effects on thyroid function of an inhibitor of tyrosine dehalogenase, 3-nitro-L-tyrosine (MNT) have been investigated in rats. In preliminary studies, marked inhibition of iodotyrosine deiodination was demonstrated in rats drinking 8 mM MNT. A series of experiments was then performed in which rats received Remington low iodine diet and 8 mM MNT as drinking fluid. This regimen had the follow...

PURPOSE To determine whether the selective BRAF inhibitor, dabrafenib, can stimulate radioiodine uptake in BRAF V600E-mutated unresectable or metastatic iodine-refractory papillary thyroid cancer (PTC). EXPERIMENTAL DESIGN Ten patients with BRAF V600E-mutant iodine-refractory PTC were enrolled. Absence of radioiodine uptake on iodine-131 whole body scan obtained within 14 months of study entr...