Sera from 20 patients with suspected or known coronary artery disease were measured for thyroxine (T4), tri-iodothyronine (T3), tri-iodothyronine uptake ratio (T3UR), thyroid stimulating hormone (TSH), and reverse tri-iodothyronine (rT3), before and after maximal or near-maximal exercise. On the average the patients achieved 92% (rang 68-108) of the predicted maximum heart rate. There were no s...

OBJECTIVE To evaluate thyroid function and hormonal profile in women with polycystic ovary syndrome (PCOS). METHODS A case-control study was conducted at Saad Abualila Center, Khartoum, Sudan. The cases were women with confirmed PCOS based on Rotterdam criteria. The controls were infertile women with no evidence of PCOS. The socio-demographic characteristics and medical history were gathered ...

Thyroid hormone has been reported to have significant effects on the peripheral vascular system, including relaxation of vascular smooth muscle cells and antiatherosclerotic effects. To exert its biological activity, thyroxine, which is a major secretory product of thyroid gland, needs to be converted to 3,5,3'-triiodothyronine (T(3)) by iodothyronine deiodinase. Type I iodothyronine deiodinase...

The perirenal adipose tissue is the main fat depot in newborn goats, and it has recently been shown to represent functional "brown fat" [l]. In the rat, brown adipose tissue contains a high activity of the iodothyronine 5'deiodinase enzyme system which converts thyroxine to the active thyroid hormone, 3,3',5-triiodothyronine [see 21. Iodothyronine 5'deiodinase exists in two major forms, termed ...

Biosynthesis of iodothyronines in thyroglobulin occurs by oxidative coupling of two iodotyrosine residues catalyzed by thyroperoxidase. To study the mechanism of iodothyronine formation, iodine-free thyroglobulin was non-enzymatically iodinated and after removal of non-incorporated iodide, incubated with lactoperoxidase and glucose oxidase between pH 4 and 9. The amount of thyroxine (T4). 3,5,3...

A method is described for the determination of serum thyroxine using ion-exchange resin sponges. The principle is based on the use of protein-binding sites and part of the technique is similar to the Triomet resin uptake test. An isotope extraction recovery procedure is incorporated in the method. Studies of factors influencing the analysis are reported and the results of tests of accuracy, pre...

Thyroid hormones play important roles in bone growth, development, and turnover. To exert its biological activity, T(4) needs to be converted to T(3) by iodothyronine deiodinase. In human thyroid gland as well as rat brown adipose tissue, type 2 iodothyronine deiodinase (D2) expression is regulated by a TSH receptor-cAMP-mediated mechanism. TSH receptor knockout mice demonstrated the direct eff...

OBJECTIVE To evaluate urinary iodine excretion during the course of pregnancy and postpartum in relation to maternal and neonatal thyroid function parameters in Saudi women living in Jeddah, Kingdom of Saudi Arabia. METHODS A prospective longitudinal study was conducted on Saudi normal pregnant women during the course of pregnancy (N=80), at term and 6-10 weeks postpartum (N=65), during the p...

to evaluate the concentrations of serum lipids and lipoproteins and their correlations together and withthyroid hormones in gray necked ostrich (struthio camelus), the serum levels of cholesterol, triglyceride,total lipids, very low density lipoproteins (vldl-cholesterol), low density lipoproteins (ldl-cholesterol)and high density lipoproteins (hdl-cholesterol) and their correlations with tri-i...

The effects of amiodarone on thyroid function tests in 100 patients treated for 6 weeks to 8 years are reported. One patient became thyrotoxic and 10 developed latent or overt hypothyroidism. Twenty-five patients remained clinically euthyroid throughout, but had free thyroxine indices above the normal range. In these patients with apparently anomalous results, total tri-iodothyronine was normal...