نتایج جستجو برای: iron chelating agents
تعداد نتایج: 503491 فیلتر نتایج به سال:
Differentiating agents have been proposed to overcome the impaired cellular differentiation in acute myeloid leukemia (AML). However, only the combinations of all-trans retinoic acid or arsenic trioxide with chemotherapy have been successful, and only in treating acute promyelocytic leukemia (also called AML3). We show that iron homeostasis is an effective target in the treatment of AML. Iron c...
BACKGROUND Researchers are exploring the effects of adding treatments to the main antimalarial regimens in an attempt to reduce mortality from Plasmodium falciparum. Iron chelation is one potential chemotherapeutic adjuvant treatment. Before advocating adjunctive therapy, the effects of iron chelators in improving patient outcomes need to be examined. OBJECTIVES To assess the effects of iron-...
Iron in man is held within the cells incorporated in organic complex molecules, either as functional iron, i.e., hemoglobin and tissue enzymes, or as storage iron, i.e., ferritin and hemosiderin. Owing to the requirements of the erythroid marrow in particular, large amounts of iron must constantly pass from one cell to another through the plasma. This plasma transport is brought about by a #3gl...
Microbial iron chelates, called siderophores, are synthesized by bacteria and fungi in response to low iron availability in the environment. The present review summarizes structural details of siderophore ligands with respect to their transport properties. This presentation is largely centred on the occurrence and function of siderophores in the various bacterial and fungal genera.
Bis-(hydroxyamino)triazines (BHTs) constitute a new, general and highly versatile group of tridentate iron(III) chelating agents exhibiting higher affinity to iron(III) than other tridentate iron(III) chelators and superior iron(III) over iron(II) selectivity compared to desferrioxamine-B (DFO), EDTA as well as other tridentate ligands.
Desorption of metal ions from oxygen-bleached hardwood and softwood kraft pulps by different chelation treatments were studied. The main focus was on desorption of manganese, iron, and magnesium ions, but also on desorption of some other common metal ions. The metal ion concentrations were determined by the DCP-AES and ICP-MS techniques. Acid treatments with nitric and oxalic acids removed mang...
Further experience with the differential ferrioxamine test (Fielding, 1965) for the measurement of body-iron chelation has led to modifications which include (1) an improved standard for the estimation of ferrioxamine, (2) simplified preparation of the test dose, (3) restriction of fluid during the test and (4) simplified methods of calculation. The principle of the test remains the same: an in...
The neisserial fbpABC locus has been proposed to act as an iron-specific ABC transporter system. To confirm this assigned function, we constructed an fbpABC mutant in Neisseria meningitidis by insertional inactivation of fbpABC with a selectable antibiotic marker. The mutant was unable to use iron supplied from human transferrin, human lactoferrin, or iron chelates. However, the use of iron fro...
The haemolytic activity of iron-dextran complex is found to be a function of time, temperature, pH, and concentration. The lytic action is enhanced by small amounts of added ferrous sulphate. The lytic action is inhibited by chelating agents such as citrate and sequestrene salts, which bind ionic iron, but not by ferric citrate or ferric sequestrene which do not bind iron. The ionised iron cont...
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