نتایج جستجو برای: irp
تعداد نتایج: 562 فیلتر نتایج به سال:
Post-transcriptional regulation of mRNA translation and stability in iron metabolism involves the interaction between the trans-acting cytoplasmic iron regulatory proteins (IRP-1 and IRP-2) and cis-acting iron-responsive elements (IREs) in mRNA 5'- or 3'-untranslated regions. IRP-1 can adopt two conformations: one with a [4Fe-4S]-cluster, unable to bind IREs, which functions as a cytoplasmic ac...
Iron regulatory protein-1 (IRP-1) controls the expression of several mRNAs by binding to iron-responsive elements (IREs) in their untranslated regions. In iron-replete cells, a 4Fe-4S cluster converts IRP-1 to cytoplasmic aconitase. IRE binding activity is restored by cluster loss in response to iron starvation, NO, or extracellular H2O2. Here, we study the effects of intracellular quinone-indu...
BACKGROUND The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection. METHODS A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-conf...
PURPOSE To explore potential design for pharmacogenomics trials in sepsis, we investigate the interaction between pharmacogenomic biomarkers and response to drotrecogin alfa (activated) (DrotAA). This trial was designed to validate whether previously identified improved response polymorphisms (IRPs A and B) were associated with an improved response to DrotAA in severe sepsis. METHODS Patients...
Both policy debate and research have focused on the linkage between the availability and generosity of public disability benefits and the reduction in the work effort of older men. That linkage is the subject of this paper. First, quantitative research in the area is reviewed and the differences in the results are examined. Results differ owing to differences in (1) model specification, (2) the...
In this paper I estimate the inflation risk premium (IRP) using a low- dimensional arbitrage free dynamic model through novel strategy. Instead of modeling nominal and real yields jointly, make assumptions about short-term rate. More specifically, assume it follows Gaussian process. This framework has closed-form expression for IRP. Since are not observed, to parameters approximate them by brea...
In its aconitase-inactive form, IRP-1 (iron regulatory protein-1)/cytosolic aconitase binds to the IRE (iron-responsive element) of several mRNAs to effect post-transcriptional regulation. We have shown previously that IRP-1 has ATPase activity and that binding of ATP suppresses the IRP-1/IRE interaction. In the present study, we characterize the binding activity further. Binding is observed wi...
TO THE EDITOR: Abdallah and Fass recently reported an interesting case of a patient with dysphagia who was initially diagnosed with Jackhammer esophagus (JE) and progressed to type 2 achalasia over the course of approximately 2 years. We read this report with great interest as our group has studied the natural course of JE and has also found progression of JE to achalasia, which we reported pre...
BACKGROUND Immune-related pancytopenia (IRP) is characterized by pancytopenia caused by autoantibody-mediated bone marrow destruction or suppression. The bone marrows of IRP patients have remarkably increased erythroblastic islands (EIs). METHODOLOGY AND PRINCIPAL FINDINGS We determined the immunoglobulin G (IgG) autoantibodies in some parts of EIs of IRP patients using immunofluorescence to ...
Genetic ablation of iron regulatory protein 2 (IRP-2), a protein responsible for post-transcriptional regulation of expression of several iron metabolism proteins, predisposes IRP-2 -/- mice to develop adult onset neurodegenerative disease. Ferric iron reproducibly accumulates within axonal tracts and neuronal cell bodies in discrete regions of the brain, and areas of iron accumulation colocali...
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