a School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, VA 24061, USA Department of Bioengineering, Department of Mechanical Engineering and Graduate Program in Biophysics, University of California at Berkeley, Berkeley, CA 94720, USA Center for Bioengineering in the Service of Humanity and Society, School of Computer Science and Engineering, Hebrew Un...

INTRODUCTION Irreversible electroporation (IRE) is a new minimally invasive tumor ablation technique which induces irreversible disruption of cell membrane integrity by changing the transmembrane potential resulting in cell death. Irreversible electroporation is currently undergoing clinical investigation as local tumor therapy for malignant liver and lung lesions. This is the first case report...

BACKGROUND Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study, we explore the attributes of a new tissue ablation technology that simultaneously delivers a synergistic combination of electroporation and electrolysis ...

Irreversible electroporation is a novel tissue ablation technique which entails delivering intense electrical pulses to target tissue, hence producing fatal defects in the cell membrane. The present study numerically analyzes the potential impact of liver blood vessels on ablation by irreversible electroporation because of their influence on the electric field distribution. An anatomically real...

Exposing biological cells to sufficiently strong external electric fields causes electroporation of cell membranes, i.e. occurrence of transient or permanent permeable pathways between the interior and exterior of the cell. Electroporation can be used to introduce various molecules into cells (reversible electroporation) or to kill cells (irreversible electroporation), which can in turn be used...

Surfactant polyoxyethylene glycol (C12E8) decreases the voltage required for irreversible electroporation in planar lipid bilayers. In our study the effect of non-cytotoxic concentration of C12E8 on cell membrane reversible and irreversible electroporation voltage was investigated in DC3F cell line. Cell suspension was exposed to a train of 8 electric pulses of 100 ms duration, repetition frequ...