Background CD177 is a surface protein on neutrophils and main mediator for the expression of proteinase 3 (PR3). Its functions are largely unknown. At least three types antibodies have been described to target CD177: isoantibodies, which formed in CD177-null individuals as result an immune reaction following transfusion or pregnancy; autoantibodies present sera from patients with autoimmune neu...

The first Technical Note in this series [1] introduced the international standard ISO 10303, informally known as STEP (STandard for the Exchange of Product model data). Subsequent Technical Notes discussed various issues faced by users of STEP and how the ISO TC184/SC4 committee is addressing these issues. This paper presents the current move to modularize the STEP application protocol architec...

For example, the escape sequence "ESC 2/4 2/8 4/3" or "ESC $ ( C" indicates that the bytes following the escape sequence are Korean KSC characters, which are encoded in two bytes each. The escape sequence "ESC 2/14 4/1" or "ESC . A" indicates that ISO 8859-1 is designated to G2. After the designation, the single shifted sequence "ESC 4/14 4/1" or "ESC N A" is interpreted to represent a characte...

Purpose: Breast cancer imaging methods lack diagnostic accuracy, in particular for patients with dense breast tissue, and improved techniques are critically needed. The purpose of this study was to evaluate antibody-indocyanine green (ICG) conjugates, which undergo dynamic absorption spectrum shifts after cellular endocytosis and degradation, and spectroscopic photoacoustic (sPA) imaging to dif...

BACKGROUND Routine methods capable of assessing tissue inflammation noninvasively are currently not available. We hypothesized that tissue retention of microbubbles targeted to the endothelial cell adhesion molecule P-selectin would provide a means to assess inflammation with ultrasound imaging. METHODS AND RESULTS Phospholipid microbubbles targeted to P-selectin (MB(p)) were created by conju...

Glycogen synthase kinase 3 (GSK-3 ) negatively regulates cardiac hypertrophy. A potential target mediating the antihypertrophic effect of GSK-3 is eukaryotic translation initiation factor 2B (eIF2B ). Overexpression of GSK-3 increased the cellular kinase activity toward GST-eIF2B in neonatal rat cardiac myocytes, whereas LiCl (10 mmol/L) or isoproterenol (ISO) (10 mol/L), a treatment known to i...

objective(s) several studies have reported improved response of exercised hearts to myocardial infarction (mi). this study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (tbars), total antioxidant status (tas), lipids, and electrocardiographic (ecg) patterns in isoproterenol (iso)-induced myocardia...

Dieser Konferenzbeitrag stellt Erfolgsfaktoren und Misserfolgsfaktoren der Anwendungsentwicklung dar. Grundlage hierfür bilden empirische Untersuchungen des Jahres 2009. Diese Erfolgsund Misserfolgsfaktoren werden anhand der Klassifikation der ISO / IEC 12207 und ISO / IEC 15288 gruppiert und diskutiert. 1 Hintergrund und Basis des vorliegenden Konferenzbeitrags Dieses Paper basiert auf empiris...