N O V E L I M A G I N G O F F U N C T I O N A L C A R D I A C A N A T O M Y is possible in isolated heart preparations when a clear perfusate is used; which, in turn, provides important insights into the device-tissue interface of implanted devices such as transcatheter valves. The implantation of a transcatheter aortic valve (TAV) (CoreValve System, Medtronic, Inc., Mounds View, Minnesota) wit...

effect of perfusion with low temperature locke solution on the isolated hearts of adult rabbits and mongrel puppies was studied. the study showed no arrhythmias or myocardial fibrillation at low temperatures in the isolated mammalian heart.

Evidence is presented supporting the hypothesis that the positive inotropic effect after an abrupt increase in systolic pressure (Anrep effect) is the recovery from subendocardial ischemia induced by the increase and subsequently corrected by vascular autoregulation of the coronary bed. Major evidence consists of data obtained from an isolated heart preparation showing that the Anrep effect can...

introduction: treatment of supraventricular arrhythmia includes wide range of medical interventions. herbal remedies are suitable alternatives for synthetic drugs due to their availability, minimal side effects and lower price. pharmacological studies and traditional medical literature point to the cardiovascular effects of the artemisia absinthium l. from compositae family of plants. methods: ...

The isolated perfused heart system, as originated by Oscar Langendorff more than a century ago, has become a predominant technique in pharmacological and physiological research. The technique allows the examination of cardiac contractile strength (inotropic effects), heart rate (chronotropic effects) and vascular effects without the complications of an intact animal model. From its simple begin...

Recovery of postischemic function may be limited by energy synthesis by mitochondria, energy transfer via the creatine kinase reaction, or energy utilization at myofibrils. To identify the limiting step, we defined the relations among oxygen consumption, creatine kinase reaction velocity and cardiac performance in myocardium reperfused following mild, moderate, and severe ischemia. Isolated iso...