T-2 toxin, a trichothecene mycotoxin, is considered to be one of the most toxic compounds that are produced by molds, particularly the Fusarium species. Fusarium species have been recognized as a great agricultural problem. They occur worldwide on a variety of plant hosts and cereal grains. The aim of this study was to investigate T-2 toxin-induced liver injury using in situ perfused rat liver....

liver injury induced by viruses, chemicals and drugs can be protected by different medicinal plants. feijoa sellowiana (myrtaceae) is an evergreen bush native to southern areas of south america, as well as iran where the fruits are very popular. feijoa has shown a potent antimicrobial effect. morever, the antioxidant activity of total feijoa extract has also been reported. mdma or ecstasy is a ...

Rat lymph chylomicrons and chylomicron remnants were treated with trypsin or Pronase. The ability of the resulting apoprotein-free lipoproteins to be taken up by the isolated perfused rat liver, and to bind to isolated rat liver membranes, was examined. Compared with control lipoproteins, the apoprotein-free chylomicrons and remnants retained unaltered their capacity to be differentiated by the...

The effects of hypophysectomy on albumin and total protein synthesis in rat liver were investigated in uiuo, in perfused liver, and in isolated hepatocytes. In all systems, hypophysectomy resulted in about a 50% decrease in the rate of total protein synthesis and a 30 to 50% decrease in the relative rate of albumin synthesis. Albumin synthesis accounted for 11 to 13% of total protein synthesis ...

T-2 toxin, a trichothecene mycotoxin, is considered to be one of the most toxic compounds that are produced by molds, particularly the Fusarium species. Fusarium species have been recognized as a great agricultural problem. They occur worldwide on a variety of plant hosts and cereal grains. The aim of this study was to investigate T-2 toxin-induced liver injury using in situ perfused rat liver....

Simvastatin (SV) is a semisynthetic derivative of lovastatin (LV), which biosynthetically produced from the fungus Aspergillus terreus and has high log p value (log = 4.39)and thus hepatic extraction efficacy in controlling cholesterol synthesis. The current study was undertaken to investigate metabolic profile SV using various mass spectrometry (MS) platforms. Metabolic profiling studied vitro...

BACKGROUND Eprosartan is an angiotensin II receptor antagonist, used in the treatment of hypertension and heart failure in clinical patients. The objective of this study was to clarify the mechanism underlying hepatic uptake and biliary excretion of eprosartan in rats and humans. METHODS Perfused rat liver in situ, rat liver slices, isolated rat hepatocytes and human organic anion-transportin...