A group of arylalkyl isothiocyanates were tested for their abilities to inhibit tumorigenicity and DNA methylation induced by the esophageal-specific carcinogen, N-nitrosomethylbenzylamine (NMBA) in the F344 rat esophagus. Phenylpropyl isothiocyanate (PPITC) was more potent than either phenylethyl isothiocyanate (PEITC) or benzyl isothiocyanate (BITC). Phenylbutyl isothiocyanate (PBITC), howeve...

moringaceae, a monogeneric family in capparales (glucosinolate-containing species), includes 14 species. one of them is moringa peregrina (forssk.) fiori., a small tree, which grows in south east of iran. volatile constituents of seed coat and stem of m. peregrina were determined by gc and gc/ms. moreover, extracts of seed and different cultured cells were analyzed by tlc and gc. three volatile...

Aromatic isothiocyanates are interesting pseudohalides molecules which are widely existed in healthy intact plants. However, few attempts were made to analyze their structures and correlate their electronic structure with other properties (e.g., chemical reactivity). In this paper, the electronic structures and substituent effects of o-, m-, and piodophenyl isothiocyanates were studied by the u...

Cabbage contains the glucosinolate sinigrin, which is hydrolyzed by myrosinase to allyl isothiocyanate. Isothiocyanates are thought to inhibit the development of cancer cells by a number of mechanisms. The effect of cooking cabbage on isothiocyanate production from glucosinolates during and after their ingestion was examined in human subjects. Each of 12 healthy human volunteers consumed three ...

The ring-opening copolymerisation of a d -xylose 3,5-anyhydrosugar with isothiocyanates forms AB-type copolymers imidothiocarbonate linkages. Block copolymer synthesis, reaction kinetics, polymer degradation and metal absorption are explored.

ABSTRACT Isothiocyanates are released through enzymatic degradation of glucosinolates produced by plants in the family Brassicaceae. Glucosinolate profiles differ among plant species and the isothiocyanate derivatives differ in their toxicity to nematodes. Control of plant-parasitic nematodes in soil by isothiocyanates released from incorporated brassicaceous plant material has been inconsisten...

Our preceding papers [1 — 3] referring to the quantitative study of nucleophilic addi­ tion reactions of isothiocyanates (ITC) deal with the reactivity of alkyl and particu­ larly aryl isothiocyanates with —OH ions, amino groups (of various amines and amino acids), and thioglycolate. Results thus obtained together with further analogous ones from investigation of the reactivity of ITC with othe...

A comparison of the effect of isothiocyanates and nitriles derived from some glucosinolates, namely, epi-progoitrin, sinalbin, glucotropaeolin, glucocheirolin, and glucoraphenin, on human erythroleukemic in vitro cultured cells was studied. Many studies have in fact evidenced that a consumption of vegetable containing glucosinolates could reduce the development of colorectal cancer. In the expe...

Isothiocyanates and their naturally occurring glucosinolate precursors are widely consumed as part of a diet rich in cruciferous vegetables. When plant cells are damaged, glucosinolates are released and converted to isothiocyanates by the enzyme myrosinase. Many isothiocyanates inhibit the neoplastic effects of various carcinogens at a number of organ sites. Consequently, these agents are attra...