Colibacillosis, caused by avian pathogenic Escherichia coli (APEC) is a major problem for the poultry industry resulting in significant losses annually. Previous work in our lab and by others has shown that the increased serum survival gene (iss) is a common trait associated with the virulence of APEC. This gene was first described for its contributions to E. coli serum resistance. However, rec...

BACKGROUND: Colibacillosis, caused by different serotypes of avian pathogenic Escherichia coli (APEC), is one of the important diseases in poultry industry. The isolate O78 is the most prevalent serotype of APEC in Iran. One of the APEC virulence factors, increased serum survival (iss) gene, is related to serum resistance. The usual form of colibacillosis in avian is extraintestinal, and serum ...

We consider nonlinear systems with both control and disturbance inputs. The main problem addressed is the design of state feedback control laws, achieving ISS and integralISS disturbance attenuation, with restricted control under the assumption that an appropriate control Lyapunov function is known. Our results generalize the previous results on ISS and integral-ISS stabilization to the restric...

We consider an arbitrary number of interconnected nonlinear systems with time-delays and investigate them in view of input-to-state stability (ISS). The useful tools for single time-delay systems, the ISS Lyapunov-Razumikhin functions and ISS Lyapunov-Krasovskii functionals are redefined and applied to interconnected systems. By the help of a smallgain condition we prove that the whole system w...

No single characteristic of virulent avian Escherichia coli has been identified that can be exploited in colibacillosis detection protocols. Research in our lab suggests a strong association between the presence of an iss DNA sequence with an isolate's disease-causing ability. The study presented here focuses on the techniques used in the expression, purification, and characterization of avian ...

Intestinal intussusception (ISS) commonly causes intestinal obstruction in children. One mechanism that has been proposed to cause ISS is inflammation-induced alteration of intestinal motility. We investigated whether innate inflammatory factors or altered motility is required for induction of ISS by LPS. We compared rates of ISS among BALB/c and C57BL/6 mice, mice lacking lymphocytes or deplet...

In this paper ISS small-gain theorems for discrete-time systems are stated, which do not require input-to-state stability (ISS) of each subsystem. This approach weakens conservatism in ISS small-gain theory, and for the class of exponentially ISS systems we are able to prove that the proposed relaxed small-gain theorems are non-conservative in a sense to be made precise. The proofs of the small...

We have used a mouse model of allergen-induced airway hyperresponsiveness to demonstrate that immunostimulatory DNA sequences (ISS) containing a CpG DNA motif significantly inhibit airway eosinophilia and reduce responsiveness to inhaled methacholine. ISS not only inhibited eosinophilia of the airway (by 93%) and lung parenchyma (91%), but also significantly inhibited blood eosinophilia (86%), ...

Bacterial DNA and its synthetic immunostimulatory oligodeoxynucleotide analogs (ISS-ODN) activate innate immunity and promote Th1 and cytotoxic T-lymphocyte immune responses. Based on these activities, we investigated whether ISS-ODN could modify the course of Mycobacterium avium infection. M. avium growth in vitro was significantly inhibited by ISS-ODN treatment of human and mouse macrophages,...