BACKGROUND This study was conducted to compare the oral bioavailability of an itopride extended-release (ER) formulation with that of the reference immediate-release (IR) formulation in the fasting state. The effect of food on the bioavailability of itopride ER was also assessed. METHODS A single-center, open-label, randomized, multiple-dose, three-treatment, three-sequence, crossover study w...

A simple, sensitive and precise stability indicating HPLC method has been developed for the estimation of rabeprazole and itopride in combined dosage form. A Phenomenex Gemini C-18, 5 μm column with a mobile phase containing 0.02 M ammonium acetate (pH 6): acetonitrile: methanol (45: 20: 35, v/v/v) was used. The flow rate was 1.0 mL min and effluents were monitored at 284 nm. Rabeprazole and it...

BACKGROUND The treatment of patients with functional dyspepsia remains unsatisfactory. We assessed the efficacy of itopride, a dopamine D2 antagonist with anti-acetylcholinesterase [corrected] effects, in patients with functional dyspepsia. METHODS Patients with functional dyspepsia were randomly assigned to receive either itopride (50, 100, or 200 mg three times daily) or placebo. After eigh...

Degradation products of itopride formed under different forced conditions have been identified using LC-PDA and LC-MS techniques. Itopride was subjected to forced degradation under the conditions of hydrolysis, photolysis, oxidation, dry and wet heat, in accordance with the International Conference on Harmonization. The stress solutions were chromatographed on reversed phase C18 (250×4.6 mm, 5 ...

A wide range of dyspeptic symptoms in clinical practice reflect the high prevalence of functional disorders of the gastrointestinal (GI) tract. Prokinetic agents are the current mainstay in the therapy of functional dyspepsia. One of these drugs is itopride. We evaluated therapeutic efficacy of itopride according to the literature review. The therapeutic potential of itopride is connected with ...

Abstract Purpose Gastroretentive drug delivery systems (GRDDS) have attracted interest for enhancement of absorption and bioavailability some drugs. Itopride hydrochloride (ITOP) is a used treatment gastroesophageal reflux other gastric motility disorders, but characterized by narrow window short in vivo half-life. Therefore, it expected that its formulation expanding gastroretentive tablets wo...