AIMS Genetic research on substance use disorders usually defines phenotypes as a binary diagnosis, resulting in a loss of information if the disorder is inherently dimensional. The DSM-IV criteria for drug dependence were based on a theoretically dimensional (linear) model. Considerable investigation has been conducted on DSM-IV alcohol criteria, but less is known about the dimensionality of DS...

There are several procedures for assessment of abuse liability/potential in laboratory animals. Among them is an intravenous (IV) drug self-administration procedure that is the gold standard. For example, the IV drug self-administration procedure has high face, predictive and construct validities [1,2]. In addition, the procedure also has lower rates of false positives and negatives, relative t...

introduction: spontaneous perforation of the nasal septum is an uncommon condition. nasal inhalation of substances such as cocaine has long been linked to this perforation. case report: this report describes the case of a 46-year-old woman who was addicted to methamphetamine and who presented with perforation of the nasal septum.this is the first reported case of nasal septal necrosis linked to...

BACKGROUND DSM-IV criteria for illicit drug abuse and dependence are largely based on criteria developed for alcohol use disorders and there is a lack of research evidence on the psychometric properties of these symptoms when applied to illicit drugs. METHOD This study utilizes data on abuse/dependence criteria for cannabis, cocaine, stimulants, sedatives, tranquilizers, opiates, hallucinogen...

Drug abuse is a problem of increasing worldwide significance. In addition to the obvious socioeconomic problems associated with the use of so-called street drugs, the abuse of ethical pharmaceuticals may also result in serious untoward health effects depending upon a wide range of variables (Chiang and Goldfrank 1990). One possible medical complication of drug abuse is modulation of the immune ...

conclusions these results indicate that the epidemic of risk behavior varies in subjects according to factors including gender, the university where one studies, parents’ occupation and their income, and the number of family members. results the research indicates that 45.2% of students sometimes, mostly, or always have an improper diet, 56.5% have no physical activity, 62.3% have experienced u...

drug abuse is a problem that causes a wide array of social, emotional, and physical problems and involves both patients and the society. helping the addicted has always been a priority for physicians and especially psychiatrists. the purpose of this prospective study was to compare the effects of methadone and naltrexone in general well-being of patients undergoing these treatments.forty-six pa...

Previous research has found relatively limited acceptance of nonabstinence goals in addiction treatment settings in the United States. Because such attitudes may have changed over time, this study was designed to assess the current acceptance of nonabstinence goals by addiction professionals as a function of type of substance (alcohol vs. drug), severity of the disorder (DSM-IV abuse vs. DSM-IV...

background: substance abuse is one of the most complicated social problems. understanding socio-demographic characteristics of those who abuse substances could help deal with this problem more efficiently. the main objective of this study was to determine socio-demographic characteristics associated with alcohol drinking, cigarettes smoking and drug abuse among a sample of male medical universi...

methamphetamine hydrochloride is a white to light brown crystalline powder, or clear chunky crystals resembling ice. the majority of street methamphetamine is produced in clandestine laboratories. the drug manufacturer states that patients should be informed that methamphetamine and amphetamine may impair the ability to engage in potentially hazardous activities such as driving a motor vehicle....