Human JL-calpain is activated maximally by 100-200 JLM Ca2+. Both the 80 kDa and 29 kDa subunits of JL-calpain have a EF-hand type calcium-binding domain. It is known that trivalent terbium ion (Tb3+) mimics Ca2+ in many biological systems. We found that Tb3+ alone transiently activated calpain. However, in the presence of Ca2+ , Tb3+ inhibited JL-calpain with an IC5o of about loo JLM. As high ...

This paper analyzes circulant Johnson-Lindenstrauss (JL) embeddings which, as an important class of structured random JL embeddings, are formed by randomizing the column signs of a circulant matrix generated by a random vector. With the help of recent decoupling techniques and matrix-valued Bernstein inequalities, we obtain a new bound k = O(ǫ log(n)) for Gaussian circulant JL embeddings. Moreo...

Let JL be a positive Borel measure with support supp JL = E C -1,1) and let