A functional B cell antigen receptor is thought to regulate antibody gene rearrangement either by stopping further rearrangement (exclusion) or by promoting additional rearrangement (editing). We have developed a new model to study the regulation of antibody gene rearrangement. In this model, we used gene targeting to replace the J kappa region with a functional V kappa-J kappa light chain gene...

Abstract In this paper, we consider the small-convection limit of chemotaxis-Navier–Stokes system with logarithmic sensitivity and logistic-type source $$ \textstyle\begin{cases} n^{\kappa}_{t}+\boldsymbol{u}^{\kappa}\cdot \nabla{n}^{\kappa}= \Delta{n}^{\kappa}-\chi \nabla \cdot ({n^{\kappa}}\nabla \log{c^{\kappa}})+f(n^{\kappa}), &x\in \Omega , t>0, \\ c^{\kappa}_{t}+\boldsymbol{u}^{\ka...

background and objectives: antibacterial susceptibility testing of clinical bacterial isolates through disk diffusion method plays a major role in antibacterial treatment. one of the main factors affecting the result of these tests is the type, structure and quality of the disks. the main objective of this study was to compare the agreement of antibiotic disks originated from three companies on...

objective: to examine the inter-rater reliability of triages performed by the electronic triage system (ets) which has recently developed and used in hospital emergency department (ed). methods: this cross-sectional study was conducted prospectively and studied 408 visitors of tabriz imam reza hospital’s ed. the variables of interest were age, sex, nurse-assigned triage category, physician-assi...

To determine whether a foreign unrearranged immunoglobulin gene can be functionally rearranged and expressed in vivo, a rabbit b9 kappa light chain gene construct containing a single germ-line kappa chain variable (V) region gene (V kappa), the five kappa chain joining (J) segments (J kappa), and the kappa chain constant (C) region germ-line gene (C kappa) was introduced into fertilized mouse e...

The V kappa10 family of murine light chain Ig genes is composed of three members, two of which (V kappa 10A and V kappa 10B) are well used. V kappa 10C, the third member of this family, is not detected in any expressed Abs. Our previous work showed that V kappa 10C is structurally functional and can recombine, but mRNA levels in spleen were extremely low relative to those of V kappa 10A and V k...