نتایج جستجو برای: karyogram
تعداد نتایج: 33 فیلتر نتایج به سال:
A 74-year-old man with colorectal carcinoma treated with surgery and adjuvant chemotherapy with oxaliplatin and fluorouracil 6 years previously was admitted with fever and suspicion of sepsis. Laboratory tests showed hemoglobin 137 g/L, mean corpuscular volume 94.7 fL, platelets 177 109/L, leukocytes 2.0 109/L, and neutrophils 0.8 109/L. Within 4 days his condition deteriorated rapidly with pro...
The use of next-generation sequencing technologies to produce genomic copy number data has recently been described. Most approaches, however, reply on optimal starting DNA, and are therefore unsuitable for the analysis of formalin-fixed paraffin-embedded (FFPE) samples, which largely precludes the analysis of many tumour series. We have sought to challenge the limits of this technique with rega...
Purpose Mutations in the gene encoding Gasdermin A3 (Gsdma3) have been described to cause severe skin phenotypes, including loss of sebaceous glands and alopecia, in mice. We discovered a novel C-terminal mutation in Gsdma3 in a new mouse line and characterized a less frequently reported corneal phenotype, likely caused by degeneration of Meibomian glands of the inner eyelid. Methods We used ...
In eukaryotes, 45S rRNA genes are arranged in tandem arrays of repeat units, and not all copies are transcribed during mitosis. DNA methylation is considered to be an epigenetic marker for rDNA activation. Here, we established a clear and accurate karyogram for Jatropha curcas L. The chromosomal formula was found to be 2n=2x=22=12m+10 sm. We found that the 45S rDNA loci were located at the term...
Chromosome morphometry and nuclear DNA content are useful data for cytotaxonomy and to understand the evolutionary history of different taxa. For the genus Bromus Linnaeus, 1753, distinct ploidy levels have been reported, occurring from diploid to duodecaploid species. The geographic distribution of Bromus species has been correlated with chromosome number and ploidy level. In this study, the a...
Karyotype analysis was performed on the scleractinian coral Coelastrea aspera Verrill, 1866, commonly found along temperate coasts in Japan (30-35°N) and in coastal waters in the Indian and Pacific oceans. G-banding of Coelastrea aspera was successfully performed, although the banding pattern was not as clear as that in mammals. The karyogram clearly revealed that this coral had a homogeneously...
Abstract Objectives Recent advances in genetics are shedding light on previously unknown topics male infertility the last decade, thus gaining higher importance to these diagnostics. Meanwhile, therapeutic management become often determined by novel genetic/epigenetic findings, therefore, it is essential for practising andrologists have an adequate knowledge armamentarium. Methods To assess ind...
Chromosome analysis on clinical leukemia material was done by means of flow cytometry (flow karyotyping) to investigate the applicability of this technique in the detection of leukemia-associated abnormalities. Flow karyotyping was performed on blood or bone marrow samples from eight patients with chronic myelocytic leukemia (CML) after a culture period of four days and arresting the cells in m...
INTRODUCTION the chromosomes of the probands by investigating Mental retardation (MR) affects approximately 1-3 % of chromosome numbers and or chromosomal the general population in the United States (Higgins et abnormalities. If karyotype is normal then fragile X al., 2004) but this figure would be higher in developing testing is performed. Afterward, on the basis of clinical countries because ...
Cytogeneticists before I960 recognized only two pairs of satellited chromosomes in man: a large acrocentric pair of the D group and a small acrocentric pair of the G group. In I960 another pair of the D chromosomes was found to be satellited, and in I96I Ferguson-Smith and Handmaker presented conclusive evidence of all I0 acrocentric autosomes having satellites, though usual staining methods ra...
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