Hidroacanthoma simplex (HAS), also known as intraepidermal eccrine poroma, is a rare eccrine adnexal tumor that tends to be misdiagnosed as other types of benign skin tumor, including clonal seborrheic keratosis. Notably, HAS is sometimes misdiagnosed and treated by cryosurgery as seborrheic keratosis, which could trigger the later development of porocarcinoma. Therefore, accurate diagnosis of ...

Background: Seborrheic keratosis is a common benign tumor and many modalities are used to treat it. No convincing data favors the therapeutic effect of calcipotriol on seborrheic keratosis. We aimed to assess the efficacy of calcipotriol in the treatment of this tumor.Method: Eligible patients aged over 40 years with seborrheic keratosis (size: 5-15mm) were instructed to apply 50?g/g calcipotri...

Purpose To report a case of seborrheic keratosis of the inner canthus presenting as cutaneous horn. Observation A 67-year-old Asian male presented with a rod-shaped, pedunculated mass on his inner canthus. The mass grew rapidly and within 2 months measured 3.0 cm in length and 0.5 cm in diameter. It was completely excised and submitted for microscopic examination. The specimen consisted of a ...

Aberrations of the p53 gene in 27 solar keratoses were examined by the polymerase chain reaction and single-strand conformation polymorphism and DNA sequencing analyses. In a series of Japanese patients, eight of 27 cases (30%) of solar keratosis showed structural abnormalities of the p53 gene. Six of eight aberrations of p53 gene were determined to be single nucleotide substitutions, and five ...