One titrimetric and two spectrophotometric methods are described for the determination of ketotifen fumarate (KTF) in bulk drug and in tablets using cerium(IV) as the oxidimetric agent. In titrimetry (method A), the drug was treated with a measured excess of cerium(IV) in H2SO4 medium and after a standing time of 10 min, the surplus oxidant was determined by back titration with iron(II). The sp...

This study compares between unmodified carbon paste (CPE; the paste has no ion pair) and polyvinyl chloride (PVC) membrane selective electrodes that were used in potentiometric determination of ketotifen fumarate (KTF), where sodium tetraphenylborate (NaTPB) was used as titrant. The performance characteristics of these sensors were evaluated according to IUPAC recommendations which reveal a fas...

Boesenbergia thorelii extract of rhizomes and its compounds were investigated for anti-allergic activities using antigen-induced β-hexosaminidase release in RBL-2H3 cells. From bioassay-guided fractionation, the chloroform fraction was separated to afford four compounds: asaronaldehyde (1), β-sitosterol-D-glucoside (2), protocatechuic acid methyl ester (3) and 2-hydroxy-1-(3, 4-dimethoxyphenyl)...

Mast cells in inflammation, fibrosis and hypersensitivity involved. Ketotifen is a member of allergy medication that reduces inflammation. The purpose of this study was to evaluate the effect of Ketotifen on some reproductive hormones, spermatogenesis, and immune parameters in male rats. A total of 75male mice of Balb / C were selected and randomly divided into15 groups and kept in the five cag...

Objective(s): Ketotifen fumarate (KF) is a selective and noncompetitive histamine antagonist (H1-receptor) that is used topically in the treatment of allergic conditions of rhinitis and conjunctivitis. The aim of this study was to formulate and improve an ophthalmic delivery system of KF.Ocular nanoparticles were prepared with the objective of reducing the frequency of administration and obtain...