نتایج جستجو برای: killer gene
تعداد نتایج: 1161677 فیلتر نتایج به سال:
BACKGROUND NKG2D is an activating receptor expressed by natural killer and T cells, which have crucial functions in tumor and microbial immunosurveillance. Several cytokines have been identified as modulators of NKG2D receptor expression. However, little is known about NKG2D gene regulation. In this study, we found that microRNA 1245 attenuated the expression of NKG2D in natural killer cells. ...
BACKGROUND Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound interleukin-15 could kill myeloma cells with a high-risk gene expression profile in vitro and in a unique model which recapitulates human myeloma....
Killer toxins are extracellular antifungal proteins that produced by a wide variety of fungi, including Saccharomyces yeasts. Although many killer have been previously identified, their evolutionary origins remain uncertain given these genes mobilized double-stranded RNA (dsRNA) viruses. A survey yeasts from the genus has identified novel toxin with unique spectrum activity paradoxus . The expr...
Significance In order to survive, most organisms must deal with parasites. Such parasites can be other or, sometimes, selfish genes found within the host genome itself. While much is known about parasitic organisms, interaction their hosts, and ability spread between species, less genes. We here identify a “spore killer” gene in fungus Neurospora sitophila . The appears have evolved genus but h...
English version of this article has been published in “ journal of diabetes & metabolic disorders “ with both editor-in-chiefs agreement; aims to be available for Persian language readers; http://doi.org/10.1111/j.1399-039.2007.00956.x.
Differential centrifugation of an osmotic lysate of K. lactis protoplasts showed that the linear DNA killer plasmids of K. lactis, pGKL1 and pGKL2, are almost exclusively present in the cytoplasmic fraction. This fractionation procedure allows the rapid isolation of large amounts of plasmid DNA without contamination by chromosomal and mitochondrial DNA. With these DNA preparations the size of t...
Background: To evaluate the natural innate and adaptive immunity through gene expression and cytology levels in peripheral blood mononuclear cells in patients with acute myocardial infarction (AMI), stable angina pectoris (SAP) and controls. Methods: 210 patients with AMI, 210 with SAP, and 250 clinical controls were recruited. Whole human genome microarray analysis was performed in 20 randomly...
To study in vivo CD8 T cell differentiation, we quantified the coexpression of multiple genes in single cells throughout immune responses. After in vitro activation, CD8 T cells rapidly express effector molecules and cease their expression when the antigen is removed. Gene behavior after in vivo activation, in contrast, was quite heterogeneous. Different mRNAs were induced at very different tim...
Thymocytes after T-lineage commitment develop in the T-cell pathway. However, in a recent study, Li et al. (2010) demonstrated that inducing to delete Bcl11b gene in these thymocytes, even in mature T cells turns these cells into natural killer (NK) cells during the culture. They called this conversion 'reprogramming', and the reprogrammed killer cells 'ITNK cells'. The ITNK cells possessed tum...
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