Nguyen, D., O'Brien, R., Kim, J., Huang, C., Wilton, L., Greer, P., Legge, K., Booth, J., Poulsen, P., Martin, J., Keall, P. (2017). The first clinical implementation of a real-time six degree of freedom target tracking system during radiation therapy based on Kilovoltage Intrafraction Monitoring (KIM). Radiotherapy and Oncology, 123(1), 37-42. <a href="http://dx.doi.org/10.1016/j.radonc.2017.0...

In the megavoltage energy range although the mass attenuation coefficients of different bones do not vary by more than 10%, it has been estimated that a simple tissue model containing a single-bone composition could cause errors of up to 10% in the calculated dose distribution. In the kilovoltage energy range, the variation in mass attenuation coefficients of the bones is several times greater,...

There is a growing interest in patient exposure resulting from an x-ray imaging procedure used in image-guided radiation therapy. This study explores a feasibility to use a commercially available optically stimulated luminescence (OSL) dosimeter, nanoDot, for estimating imaging radiation exposure to patients. The kilovoltage x-ray sources used for kV-cone-beam CT (CBCT) imaging acquisition proc...

Background: Keloids are benign fibrous dermal tumors origina ng from skin injury a er surgery, piercing or others wounds. Materials and Methods: Sixty -two pa ents with keloids were treated postopera vely using orthovoltage irradia on. The total dose delivered was 12 Gy in three consecu ve days, 4Gy per frac on. Treatment started 24 h a er surgery. The median follow-up was 44.5 months. Results:...

Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. This review introduces the field of nanotechnology with a focus on recent gold nanoparticle research which has led to early-phase clinical trials. In particular, the pre-clinical evidence for gold nanoparticles as sensitis...

The sharp dose gradients in intensity-modulated radiation therapy increase the treatment sensitivity to various interand intra-fractional uncertainties, in which a slight anatomical change may greatly alter the actual dose delivered. Image-guided radiotherapy refers to the use of advanced imaging techniques to precisely track and correct these patient-specific variations in routine treatment. I...

INTRODUCTION Gold nanoparticles have been used as radiation dose enhancing materials in recent investigations. In the current study, dose enhancement effect of gold nanoparticles on tumor cells was evaluated using Monte Carlo (MC) simulation. METHODS We used MCNPX code for MC modeling in the current study. A water phantom and a tumor region with a size of 1×1×1 cm3 loaded with gold nanopartic...

BACKGROUND AND PURPOSE Optimal tube voltage and tube current settings are not well established. The purpose of our study was to investigate the image quality on 3D CT angiograms of the brain at various kilovoltage settings by evaluating the depiction of simulated intracranial lesions by using a vascular phantom. MATERIALS AND METHODS An anthropomorphic vascular phantom with superimposed bone ...