introduction: several mechanisms were introduced as causes of serum creatinine phosphokinase (cpk) raise in intoxicated patients. this study aimed to assess the relationship between serum cpk level in the first 24 hours and baseline characteristics as well as outcomes of these patients. methods: this one year retrospective cross-sectional study was conducted on all intoxicated patients, who wer...

background and objective: inflammatory pseudotumor  is a lesion composed of proliferating spindle cells with mixed inflammatory infiltrates. some authors have proposed the name inflammatory myofibroblastic tumor as a proper descriptive term rather than the vague inflammatory pseudotumor. the aim of this study was to verify the myofibroblastic origin of spindle cells in idiopathic orbital inflam...

background : fms-like tyrosine kinase 3 is a tyrosine kinase receptor that plays an important role in proliferation and differentiation of hematopoietic stem cells. internal tandem duplication and tyrosine kinase domain mutation are the two most common types of fms-like tyrosine kinase 3 mutations frequently reported in acute myeloid leukemia associated with pathogenesis of this disease. the pr...

Ginsenoside F1 is a biologically active compound identified potential from Korean Panax ginseng Meyer. In the present study, the potential targets of ginsenoside F1 were investigated by computational target fishing approaches including ADMET prediction, biological activity prediction from chemical structure, molecular docking, and molecular dynamics methods. Results were suggested to express th...

Ginsenoside F1 is a biologically active compound identified potential from Korean Panax ginseng Meyer. In the present study, the potential targets of ginsenoside F1 were investigated by computational target fishing approaches including ADMET prediction, biological activity prediction from chemical structure, molecular docking, and molecular dynamics methods. Results were suggested to express th...

Integrin linked kinase (ILK) is a serine/threonine protein kinase implicated in the phosphatidylinositol 3’kinase (PI3’K) pathway. Integrin linked kinase has been investigated in different organisms such as mammalian systems (human, mice, rat), insects (Drosophila) and nematodes (Cenorhabditis elegans), however to date little data regarding ILK research on amphibians has been reported. In...

how to cite this article: fallah e, arman a, najafi m, shayegh b. effect of tamoxifen and lithium on treatment of acute mania symptoms in children and adolescents. iran j child neurol. spring 2016; 10(2):16-25. abstract objective many studies have supported the role of protein kinase c (pkc) inhibitors in the physiopathology and treatment of bipolar disorder in adults. tamoxifen is one of the d...

background: the frequency of pyruvate kinase (pk) deficiency, an autosomal recessive defect, is approximately 3 per 10,000 individuals in shiraz and surrounding areas, and is increased due to high consanguinity marriage frequency. the purpose of this study is to obtain data on the frequency and spectrum of gene mutation of pk in newborns, from shiraz and surrounding areas. materials and methods...

conclusions we showed that patients with metabolic syndrome have larger infarct size compared to control subjects. background infarct size is an important surrogate end point for early and late mortality after acute myocardial infarction. despite the high prevalence of metabolic syndrome in patients with atherosclerotic diseases, adequate data are still lacking regarding the extent of myocardia...