purpose: to report the outcomes of manual lamellar keratoplasty (lkp) in patients with delayed-onset mustard gas keratitis (mgk) and compare visual outcomes between subgroups with simultaneous or sequential klal and lkp. methods: in this retrospective, interventional study, 52 eyes of 37 male survivors of chemical warfare with mgk who underwent lkp were included. the results were evaluated with...

purpose: to determine the indications for and surgical techniques of corneal transplantation at labbafinejad medical center (lmc) from 2004 to 2007. methods: in this descriptive study, records of 756 patients who had undergone corneal transplantation from october 2004 to october 2007 were reviewed. results: overall, 504 male (64.9%) and 272 female (35.1%) subjects with mean age of 41.29±21.25 (...

stem cells located at the limbus ,  are the ultimate source for regeneration of the corneal epithelium in the normal and traumatized states.  when limbal stem cells are dysfunctional or deficient, limbal stem cell deficiency (lscd) develops. its surgical management depends on laterality and severity of corneal-limbal involvement. conventional methods of stem cell transplantation are conjunctiva...

The G-protein-linked receptor, proteinase-activated receptor-4 (PAR(4)) is activated by proteinases released into the joint during inflammation. It is unclear whether PAR(4) has a pro- or anti-nociceptive effect and whether it directly affects nerve activity. In this study, we examined the expression of PAR(4) in joints and dorsal root ganglion (DRG) neurons and whether activation of PAR(4) has...

BACKGROUND AND PURPOSE We assessed the ability of poststroke captopril and losartan treatment to reverse myogenic and endothelial dysfunction in the middle cerebral arteries of Kyoto-Wistar stroke-prone spontaneously hypertensive rats (SHRsp) that developed intracerebral hemorrhagic stroke. METHODS SHRsp were sampled before and after stroke development and after up to 37 days of captopril (50...

Proteinase-activated receptors (PAR(1)-PAR(4)) belong to a family of G protein-coupled receptors that are cleaved by proteases. Previous in vitro studies on the mouse large intestine have indicated that PAR(1) and PAR(2) were involved in regulating epithelial ion transport, but that their roles were different between the proximal and distal colon. This present study was done to elucidate the ro...

Proteinase-activated receptor (PAR)(2) is activated by trypsin-like serine proteinases and has been implicated in intestinal inflammation. However, its role in the regulation of intestinal mucosal function remains unclear. Using the intestinal epithelial cell line, SCBN, we have studied the stimulus-secretion coupling mechanisms of PAR(2)-induced epithelial chloride transport, focusing on cyclo...