نتایج جستجو برای: knock down
تعداد نتایج: 222092 فیلتر نتایج به سال:
Leishmania parasites include important pathogens and model organisms are even used for the production of recombinant proteins. However, functional genomics characterization essential genes often limited in because low-throughput technologies gene disruption or tagging absence components RNA interference. Here, we tested T7 polymerase-dependent CRISPR-Cas9 system by Beneke et al. glmS ribozyme-b...
We have previously reported an antisense technology, 'snoMEN vectors', for targeted knock-down of protein coding mRNAs using human snoRNAs manipulated to contain short regions of sequence complementarity with the mRNA target. Here we characterise the use of snoMEN vectors to target the knock-down of micro RNA primary transcripts. We document the specific knock-down of miR21 in HeLa cells using ...
Knock down efficacy of commercially available insecticides against Anopheles gambiae Nicholas K. Makworo , Vincent O. Ochieng, Dorington Ogoyi, Richard W. Mukabana
Triple A syndrome is caused by mutations in AAAS encoding the protein ALADIN. We investigated the role of ALADIN in the human adrenocortical cell line NCI-H295R1 by either over-expression or down-regulation of ALADIN. Our findings indicate that AAAS knock-down induces a down-regulation of genes coding for type II microsomal cytochrome P450 hydroxylases CYP17A1 and CYP21A2 and their electron don...
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