Research question Are there genetic determinants shared by unrelated women with unexplained recurrent early miscarriage (REM)? Design Thirty REM cases and 30 controls were selected extreme phenotype among from Eastern Brittany (France), previously enrolled in an incident case–control study on thrombophilic mutations. Cases based the number of miscarriages or live births, respectively. Periphera...

Pontine cholinergic neurotransmission is known to play a key role in the regulation of rapid eye movement (REM) sleep and to contribute to state-dependent respiratory depression. Nitric oxide (NO) has been shown to alter the release of acetylcholine (ACh) in a number of brain regions, and previous studies indicate that NO may participate in the modulation of sleep/wake states. The present inves...

Ce court article formule quelques hypothèses susceptibles d’éclairer la centralité du secret dans l’histoire des remèdes. Il évoque pour cela plantes médicinales Nouveau Monde. Entre 1492 et fin xviiie siècle, en effet, transmission de ces remèdes a souvent été perturbée par pratique secret, qui pouvait poursuivre diff&#233...

Background & Objective: Stress contributes to sleep-wake behavior in all animals. It seems that factors such as learning and memory processes can improve sleep disorders. Therefore, the present study was conducted to determine the effects of stress and learning (spatial memory) on total post-stress rapid-eye-movement (REM), non-rapid-eye-movement (NREM) and waking time in rats. Materials & Met...

Copyright: © 2012 Palagini L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Disturbances of sleep are typical of depression and are observed in between 50% and 90% of depressed subjects [1]. Most pati...

Sleep stages classification is one of the most important methods for diagnosis in psychiatry and neurology. In this paper, a combination of three kinds of classifiers are proposed which classify the EEG signal into five sleep stages including Awake, N-REM (non-rapid eye movement) stage 1, N-REM stage 2, N-REM stage 3 and 4 (also called Slow Wave Sleep), and REM. Twenty-five all night recordings...

Patients with Parkinson's disease (PD) display significant sleep disturbances and daytime sleepiness. Dopaminergic treatment dramatically improves PD motor symptoms, but its action on sleep remains controversial, suggesting a causal role of nondopaminergic lesions in these symptoms. Because the pedunculopontine nucleus (PPN) regulates sleep and arousal, and in view of the loss of its cholinergi...