.................................... ............................................................. vi CHAPTER 1. GENERAL INTRODUCTION ...................................................... 1 The History of Elemental Analysis ...................................................................... 1 ICP-MS ...............................................................................................

Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to study the spatially-resolved distribution of ruthenium and platinum in viscera (liver, kidney, spleen, and muscle) originating from mice treated with the investigational ruthenium-based antitumor compound KP1339 or cisplatin, a potent, but nephrotoxic clinically-approved platinum-based anticancer drug. Method de...

A dilution method using MnO(2) for the manganese nodule standard, JMn1, has been newly adopted to obtain accurate calibration lines. Moreover, an internal standard correction method was applied to correct changes in the sample introduction efficiency for the prime purpose of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) analysis. Using the dilution method and the cor...

The spatial distribution of chemical elements in different types of samples is an important field in several research areas such as biology, paleontology or biomedicine, among others. Elemental distribution imaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is an effective technique for qualitative and quantitative imaging due to its high spatial resolution and s...

The complete chemical analysis of natural silicates has previously been accomplished only by combining laser ablation ICP-MS with electron microprobe (EMP) analysis to provide complementary information on major element constituents. Here, we present a method for laser ablation ICP-MS analysis of major elements in silicate glasses and minerals that, when applied using a 193 nm laser system coupl...

Laser induced isotopic fractionation Previous studies of laser ablation (LA) MC-ICP-MS analysis of Cu metal and sulphides showed reduced Cu/Cu ratios compared to solution nebulisation MC-ICP-MS of the same samples [1]. The fractionation of about 30ε (parts per 10,000) was reproduced repeatedly and observed, to a smaller degree, for Ag and Sb also. This deviation, which was attributed largely to...

An initial study of the minor element, trace element, and impurities in Corning archeological references glasses have been performed using three microbeam techniques: electron probe microanalysis (EPMA), laser ablation ICP-mass spectrometry (LA ICP-MS), and secondary ion mass spectrometry (SIMS). The EPMA results suggest a significant level of heterogeneity for a number of metals. Conversely, h...

Of all the inorganic mass spectrometric techniques, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) plays a key role as a powerful and sensitive microanalytical technique enabling multi- element trace analysis and isotope ratio measurements at trace and ultratrace level. LA-ICP-MS was used to produce images of detailed regionally-specific element distribution in 20 micro...

We present a technique for the fast screening of the lead concentration in whole blood samples using laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). The whole blood sample is deposited on a polymeric surface and wiped across a set of micro-grooves previously engraved into the surface. The engraving of the micro-grooves was accomplished with the same laser system used fo...

In order to quantify and compare the uptake of aluminum oxide nanoparticles of three different sizes into two human cell lines (skin keratinocytes (HaCaT) and lung epithelial cells (A549)), three analytical methods were applied: digestion followed by nebulization inductively coupled plasma mass spectrometry (neb-ICP-MS), direct laser ablation ICP-MS (LA-ICP-MS), and flow cytometry. Light and el...