A new semisynthetic penicillin, structurally related to ampicillin, has been assigned the generic name epicillin, 6-[d-2-amino-2-(1, 4-cyclohexadienyl) acetamido]-penicillanic acid. The antimicrobial spectrum and level of activity of epicillin in vitro are similar to those of ampicillin. In studies with recent clinical isolates, these two antibiotics, when compared with carbenicillin, showed co...

To test proposals for the origin of oxygen absorption bands in the visible reflectance spectrum of Ganymede, the reflectance of condensed films of pure oxygen (O2) and O2-water mixtures and the evolution of O2 from the films as a function of temperature were determined. Absorption band shapes and positions for oxygen at 26 kelvin were similar to those reported for Ganymede, whereas those for th...

This report describes studies into the pathophysiology of heparin-induced thrombocytopenia. The IgG fraction from each of nine patients with heparin-induced thrombocytopenia caused heparin-dependent platelet release of radiolabeled serotonin. Both the Fc and the Fab portions of the IgG molecule were required for the platelet reactivity. The platelet release reaction could be inhibited by the Fc...

Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides. Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal.Studies are described of suitable cultural conditions...

Biodegradation of the polycyclic aromatic hydrocarbons of creosote by undefined bacterial cultures was shown to be accompanied by the accumulation of neutral and acidic oxidation products. Formation of a number of identified neutral products is accounted for by demonstration of anomalous actions of an arene dioxygenase on the benzylic methylene and methylene carbons of napthenoaromatic hydrocar...

Cephalexin, 7