BACKGROUND The current pilot study compares the impact of an intravenous infusion of Ringer's lactate to an acetate-based solution with regard to acid-base balance. The study design included the variables of the Stewart approach and focused on the effective strong ion difference. Because adverse hemodynamic effects have been reported when using acetate buffered solutions in hemodialysis, hemody...

INTRODUCTION Maintaining arterial blood glucose within tight limits is beneficial in critically ill patients. Upper and lower limits of detrimental blood glucose levels must be determined. METHODS In 69 patients with severe traumatic brain injury (TBI), cerebral metabolism was monitored by assessing changes in arterial and jugular venous blood at normocarbia (partial arterial pressure of carb...

Purpose: The aim of the study was to evaluate mortality prediction performances delta bicarbonate, anion gap, and ratio in methanol poisoning (MP) cases.
 Materials Methods: This clinical study, which followed a cross-sectional design, involved patients with MP who were still alive when they initially arrived at emergency department tertiary care hospital. Patients divided into two groups ...

Background: Blood gas and acid base values are very much essential for health assessment disease diagnosis of captive elephants especially when clinical signs were nonspecific other diagnostic techniques may not be available immediate applications. Region specific normal healthy animal profile is valuable in care planning elephants. The aim this study was to assess evolve the baseline reference...

Exposure of nervous tissue to hypoxia results in interstitial acidification. There is evidence for concomitant decrease in extracellular pH to the increase in tissue lactate. In the present study, we used double-barrelled pH-sensitive microelectrodes to investigate the link between lactate transport and acid-base homeostasis in isolated rat spinal roots. Addition of different organic anions to ...

Acute alterations in plasma bicarbonate concentration have minimal effects on intracerebral pH and cerebral blood flow, perhaps due to blood-brain barrier mechanisms. To test this hypothesis, the consequences of an acute rise in the plasma bicarbonate concentration were studied in anesthetized rats previously subjected to an acute pressure pulse in the carotid system with unilateral damage to t...

BACKGROUND Individual time to peak blood bicarbonate (HCO3-) has demonstrated good to excellent reproducibility following ingestion of both 0.2 g kg-1 body mass (BM) and 0.3 g kg-1 BM sodium bicarbonate (NaHCO3), but the consistency of the time trial (TT) performance response using such an individualised NaHCO3 ingestion strategy remains unknown. This study therefore evaluated the reproducibili...

BACKGROUND High serum lactate is associated with increased mortality in septic shock patients. Metformin alters lactate metabolism, and may affect its prognostic value. We compared, between metformin users and nonusers, the prognosis of extremely elevated plasma lactate levels in patients with septic shock. METHODS The electronic medical records (EMR) of patients admitted to the emergency roo...

Introduction : The recent development of liquid state Dynamic Nuclear Polarization (DNP) techniques has dramatically increased the signal available from C MRS experiments and has opened up new possibilities for metabolic imaging of the heart [1]. Oxidative decarboxylation of DNP hyperpolarized [1-C]pyruvate, mediated by the pyruvate dehydrogenase (PDH) complex, is a critical reaction that produ...

Overwhelming hypoxic acidosis due to poor tissue oxygen delivery from low cardiac output, pulmonary failure, and other causes has devastating effects postoperatively on patient outcome. Whereas conventional therapeutics often can not reverse the downward spiral of these patients, dichloroacetate (DCA) has been shown to be beneficial. This study investigated the metabolic and hemodynamic effects...