Poly(DL-lactide-co-glycolide) (PDLLGA) and poly(L-lactide-co-glycolide) (PLLGA) copolymers were prepared by bulk ring opening polymerization of lactide and glycolide and characterized by GPC, FTIR, 1H NMR and DSC. Copolymers with different molar masses at a constant lactide/glycolide ratio were used for preparation of bovine serum albumin (BSA)-loaded microparticles by the double emulsion w/o/w...

-To obtain more insight in the ring-opening polymerization of lactones, complex formation of the initiators tetraphenyltin, stannous octoate, tin tetrachloride, aluminium bromide and triisobutylaluminium (TIBA), and the monomers L(-)-lactide, D,e-lactide and glycolide was studied by i.r.-spectroscopy. When equimolar benzene or toluene solutions of initiators and monomers were combined, only com...

A series of zinc(II) and magnesium(II) alkoxides based upon a beta-diiminate ligand framework has been prepared. [(BDI-1)ZnO(i)Pr](2) [(BDI-1) = 2-((2,6-diisopropylphenyl)amido)-4-((2,6-diisopropylphenyl)imino)-2-pentene] exhibited the highest activity and stereoselectivity of the zinc complexes studied for the polymerization of rac- and meso-lactide to poly(lactic acid) (PLA). [(BDI-1)ZnO(i)()...

This article reports experimental data related to the research article entitled "Poly(malic acid-co-l-lactide) as a Superb Degradation Accelerator for Poly(l-lactic acid) at Physiological Conditions" (H.T. Oyama, D. Tanishima, S. Maekawa, 2016) [1]. Hydrolytic degradation of poly(l-lactic acid) (PLLA) blends with poly(aspartic acid-co-l-lactide) (PAL) and poly(malic acid-co-l-lactide) (PML) oli...

Enantiomeric stereo random copolymers (SRCs), l-lactic acid-rich poly (lactic acid)s (L -PLAs) and d-lactic (D-PLAs) with major monomer unit fraction down to 85% were synthesized from mixtures of l- acids their stereocomplex (SC)- homo-crystallization the melt investigated. The obtained results compared those previously reported for enantiomeric SRCs, l-lactide-rich (l-lactide-co-d-lactide)s d-...

We study the adsorption and ring-opening of lactide on the naturally chiral metal surface Pt(321)(S). Lactide is a precursor for polylactic acid ring-opening polymerization, and Pt is a well known catalyst surface. We study, here, the energetics of the ring-opening of lactide on a surface that has a high density of kink atoms. These sites are expected to be present on a realistic Pt surface and...

The present study was aimed to replace the alum type adjuvant for hepatitis B vaccine. The hepatitis B vaccine was encapsulated in poly (DL-lactide-co-glycolide) microspheres by solvent evaporation technique. The formulated microspheres were characterized in terms of morphology, particle size analysis, in vitro release study and in vivo immune response in male Wistar rats. The FT IR spectrum il...

s / Journal of Controlled Release 72 (2001) 225 –309 247 Introduction Biotechnology has evolved to the point that it is possible to prepare therapeutic genes for most diseases. The use of these new medicines is hampered by the lack of a suitable carrier system that helps the DNA in reaching the target cells and in the intracellular trafficking. Cationic polymers have been proposed as vectors fo...

Computational techniques predict the barrier performance of poly(lactide) composites, studying relationship between free volume, polymer morphology and gas diffusion.

Poly (DL-lactide)/Poly (ethylene glycol) diblock copolymer is successfully synthesized with mPEG and DL-LA as main raw materials, the residual monomers of polymer were removed by recrystallization. FT-IR used to characterize structure polymer. Gas chromatography determine solvent The solubility in different solvents was determined, effect systems on removal discussed. results showed that Poly(D...