Background—Steady laminar flow is atheroprotective, in part because of its antiinflammatory effects on vascular endothelial cells (ECs). We studied the activation of peroxisome proliferator–activated receptor(PPAR ) in ECs in response to laminar flow and the associated antiinflammatory effect. Methods and Results—Using flow channel with cultured ECs, we found that laminar flow activated the PPA...

The transition to turbulence in pipe and plane Couette flow differs from the better understood situation of Taylor-Couette or Rayleigh-Bénard flow in that the laminar profile is stable against infinitesimal perturbations for all Reynolds numbers. Moreover, even when turbulent flow is established, it can spontaneously return to laminar flow. These observations are compatible with the formation o...

Swifts are among the most aerodynamically refined gliding birds. However, the overlapping vanes and protruding shafts of their primary feathers make swift wings remarkably rough for their size. Wing roughness height is 1-2% of chord length on the upper surface--10,000 times rougher than sailplane wings. Sailplanes depend on extreme wing smoothness to increase the area of laminar flow on the win...

Three-dimensional simulations of the single-phase laminar flow and forced convective heat transfer of water in microchannels with small rectangular sections having specific hydraulic diameters and distinct geometric configurations were investigated numerically. The numerical results indicated that the laminar heat transfer was to be dependent upon the aspect ratio and the ratio of the hydraulic...

In this paper, the oscillating two-dimensional laminar flow about a cylinder and the oscillation of a cylinder in still water are studied. A finite volume method is applied to solve the Navier Stokes equations using SIMPLEC algorithm on a body fitted co-located O-type grid. In this study, the non-dimensional flow numbers, Keulegan-Carpenter and Stokes’ numbers are chosen over a range where diff...

BACKGROUND Steady laminar flow is atheroprotective, in part because of its antiinflammatory effects on vascular endothelial cells (ECs). We studied the activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) in ECs in response to laminar flow and the associated antiinflammatory effect. METHODS AND RESULTS Using flow channel with cultured ECs, we found that laminar flow acti...

1 The flow properties at the leading edge of a flat plate represent a singularity to the Blasius laminar boundary layer equations; by applying the Lagrangian approach the leading edge velocity profiles of the laminar boundary layer over a flat plate are studied. Experimental observations as well as the theoretical analysis show an exact Gaussian distribution curve as the original starting profi...

We investigated the effect of hemodynamic shear forces on the expression of adhesive molecules, E-selectin, and intercellular adhesion molecule-l (ICAM-1) on human umbilical vein endothelial cells (HUVEC) exposed t o laminar (8 dynes/ cmz) or turbulent shear stress 18.6 dyneslcrn' average), or to a static condition. Laminar flow induced a significant timedependent increase in the surface expres...

In this paper, the oscillating two-dimensional laminar flow about a cylinder and the oscillation of a cylinder in still water are studied. A finite volume method is applied to solve the Navier Stokes equations using SIMPLEC algorithm on a body fitted co-located O-type grid. In this study, the non-dimensional flow numbers, Keulegan-Carpenter and Stokes’ numbers are chosen over a range where diff...

Steady laminar flow in the straight parts of the arterial tree is atheroprotective, whereas disturbed flow with oscillation in branch points and the aortic root are athero-prone, in part, because of the distinct roles of the flow patterns in regulating the cell cycle of vascular endothelial cells (ECs). To elucidate the molecular basis underlying the endothelial cell cycle regulated by distinct...