نتایج جستجو برای: lamotrigine monotherapy
تعداد نتایج: 16820 فیلتر نتایج به سال:
BACKGROUND Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total of 722 drug-exposed pregnancies are needed to identify a sevenfold increase in the rate of occurrence of a specific abnormality, such as spina bifida, with a frequency of 1 in 1,000. METHODS The infants with major malformations born to t...
OBJECTIVE The treatment of pediatric bipolar depression has not been well studied. The authors wished to prospectively study the efficacy of lamotrigine as adjunctive or monotherapy in adolescents with bipolar disorder who were experiencing a depressive episode. METHOD This was an 8-week open-label trial of lamotrigine with 20 adolescents ages 12-17 years (mean age 15.8; 7 boys, 13 girls) wit...
The full effects of lamotrigine on photo and pattern sensitivity have never been fully studied, although there is some small indication in the literature of a possible beneficial effect. It is the policy of Birmingham Brainwave to substitute lamotrigine for valproate in young women who wish to become pregnant, who have primary generalized epilepsy: we use it as first-line monotherapy in young w...
The full effects of lamotrigine on photo and pattern sensitivity have never been fully studied, although there is some small indication in the literature of a possible beneficial effect. It is the policy of Birmingham Brainwave to substitute lamotrigine for valproate in young women who wish to become pregnant, who have primary generalized epilepsy: we use it as first-line monotherapy in young w...
Lamotrigine is an antiepileptic drug used for the treatment of epilepsy, bipolar disorder and numerous off-label uses. The development of rash significantly affects its use. The most concerning of these adverse reactions is Stevens-Johnson syndrome/toxic epidermal necrolysis. We performed a systematic review of randomized controlled trials using lamotrigine as a monotherapy to quantify the inci...
Startle-induced seizures are reflex seizures precipitated by a sudden, surprising stimulus, usually auditory. Aetiologies, electroencephalographic correlates, and brain structural abnormalities are variable. Because of the frequent tonic component at onset, falling is a major clinical problem. There is no established drug of choice, and therapy is often unsatisfactory. Adjunctive lamotrigine th...
OBJECTIVE Little information is available on the need for dosage changes for lamotrigine in pregnant women with bipolar disorder. The authors present new data on serial serum levels of lamotrigine in pregnant patients on lamotrigine monotherapy. They also review the epilepsy literature on use of lamotrigine during pregnancy. METHOD Lamotrigine serum samples were obtained from eight mother-inf...
The Canadian Network for Mood and Anxiety Treatments published guidelines for the management of bipolar disorder in 2005, with updates in 2007 and 2009. This third update, in conjunction with the International Society for Bipolar Disorders, reviews new evidence and is designed to be used in conjunction with the previous publications.The recommendations for the management of acute mania remain l...
OBJECTIVE To examine a large population with idiopathic generalised epilepsy (IGE), and estimate the overall remission rates for the IGEs and subsyndromes in a clinic based sample. Remission rates on valproate, lamotrigine, topiramate, and combinations of these antiepileptic drugs were estimated and factors predicting outcome examined. METHODS All patients with IGE were identified from a comp...
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