TSLP induces Th2 cytokine production by Th2 cells and various other types of cells, thereby contributing to Th2-type immune responses and development of allergic disorders. We found that house dust mite (HDM) extract induced TSLP production by nasal epithelial cells, suggesting that TSLP may be involved in development of HDM-induced allergic rhinitis (AR). To investigate that possibility in gre...

Inappropriate activation of TLR9 has been found to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus. TLR9 antagonists have been proposed to be therapeutic for some kinds of autoimmune diseases. In contrast, new negative regulators of TLR9 signal pathway need to be identified, and the mechanisms for the control of TLR9 response need to be fully investig...

As we move to developing object-oriented programs, the complexity traditionally found in functions and procedures is moving to the connections among components. Different faults occur when components are integrated to form higher level structures that aggregate behavior and state. Consequently, we need to place more effort on testing the connections among components. Although object-oriented te...

the objective of this study was to investigate the effect of principal components (pc) of the regression coefficients (co)variance matrix on the lactation curve, and on the formation of selection index to modify the curve, based on these pc’s, and as well to estimate additive genetic and phenotypic variances and heritability of the constructed selection index. lactation period of 301 d (5-305) ...

The relationships between testis size, hormone secretion and sperm production were studied during the spring (December) and autumn (May) in rams of two breeds with different breeding seasons and body weights (Corriedale and Australian Merino) maintained on native pastures and under natural photoperiods in Uruguay. Blood samples were collected at 20-min intervals during a 260-360-min period in 1...

late spring chilling in spring is largely the cause for limiting almond production, so finding ways to reduce the loss is a priority in horticultural research. the government in iran established sahand horticultural research station in 1968 to invest in some late flowering almond cultivars, and this resulted in seven new cultivars in 1994, which can survive the late chillings that might occur i...