BACKGROUND The risk of progression to active tuberculosis is greatest in the several years following initial infection. The extent to which latent tuberculosis infection reduces the risk of progressive disease following reexposure and reinfection is not known. Indirect estimates from population models have been highly variable. METHODS We reviewed prospective cohort studies of persons exposed...

Tuberculosis is caused by Mycobacterium tuberculosis. The approach to testing for tuberculosis depends on whether the aim is to diagnose active disease or latent infection. if active disease is suspected, it is important to identify the site of disease. Analysis of sputum specimens for mycobacteria should precede other tests. An infection should never be diagnosed as latent until active disease...

BACKGROUND Health care workers are exposed to patients with tuberculosis and are at risk of nosocomial infection. The aim of this study was to determine the prevalence and factors associated with latent tuberculosis infection among health care workers in Malaysia and also to evaluate the agreement between Quantiferon TB Gold in tube test with Tuberculin Skin Test. METHODS A cross sectional st...

Mycobacterium tuberculosis causes active tuberculosis in only a small percentage of infected persons. In most cases, the infection is clinically latent, although immunosuppression can cause reactivation of a latent M. tuberculosis infection. Surprisingly little is known about the biology of the bacterium or the host during latency, and experimental studies on latent tuberculosis suffer from a l...

introduction: limited data are available on the relationship between nutritional status and tuberculosis. the aim of this study was to evaluate and compare the body mass index (bmi) and serum albumin level in patients with active tuberculosis (atb) and latent tuberculosis (ltb). materials and methods: a cross-sectional study was conducted on 17 patients newly diagnosed with pulmonary tb  who we...

Active tuberculosis (TB) has a greater burden of TB bacilli than latent TB and acts as an infection source for contacts. Latent tuberculosis infection (LTBI) is the state in which humans are infected with Mycobacterium tuberculosis without any clinical symptoms, radiological abnormality, or microbiological evidence. TB is transmissible by respiratory droplet nucleus of 1-5 µm in diameter, conta...

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Tuberculosis (TB) remains a threat to the health of people worldwide. Infection with Mycobacterium tuberculosis can result in active TB or, more commonly, latent infection. Latently infected persons, of which there are estimated to be approximately 2 billion in the world, represent an enormous reservoir of potential reactivation TB, which can spread to other people. The immunology of TB is comp...

BACKGROUND Continuing rises in tuberculosis notifications in the UK are attributable to cases in foreign-born immigrants. National guidance for immigrant screening is hampered by a lack of data about the prevalence of, and risk factors for, latent tuberculosis infection in immigrants. We aimed to determine the prevalence of latent infection in immigrants to the UK to define which groups should ...