Over the 20-year period since the first issue of Environmental Health Perspectives was published, there has been considerable progress in the understanding of the potential toxicity of exposure to lead. Many of these advances have been reviewed in published symposia, conferences, and review papers in EHP. This brief review identifies major advances as well as a number of current concerns that p...

Lead toxicity is an important environmental disease and its effects on the human body are devastating. There is almost no function in the human body which is not affected by lead toxicity. Though in countries like US and Canada the use of lead has been controlled up to a certain extent, it is still used vehemently in the developing countries. This is primarily because lead bears unique physical...

Many colorectal liver metastases are hypovascular, and their low level of perfusion is associated with limited drug uptake and poor response rates with regional chemotherapy. We have previously shown that hepatic arterial vasoconstrictors may increase drug delivery to liver tumours, but the underlying haemodynamic changes have not been defined. Using intraoperative laser Doppler flowmetry (LDF)...

Introduction There is no known biological function for lead and any lead absorbed by man or by animal may be classified as potentially toxic. These toxic effects are many, ranging from morphological damage to tissues at higher concentrations, to lesser biochemical effects at lower concentrations. In biochemical systems lead will generally inhibit enzyme activity and result in clinical effects s...

A group of 45 male adolescents and young adults, beginning treatment for behavior disorder or learning disability, was found to exhibit increased systolic blood pressure, decreased hand-eye coordination as measured by the Pursuit-Rotor, shortened reaction times, and lowered lactic dehydrogenase, all significantly correlated with tissue (hair) lead concentrations considered to be in the normal r...