b a ckground: cutaneous leishmaniasis due to leishmania major is a serious and increasing problem affecting manyrural areas of 17 out of 31 provinces in iran. little is known about sand fly fauna and leishmaniases in eastern iran and no study has been carried out in sarbisheh county. the aim of this study was to determine sand flies composi- tion and probable leishmania infection to find the pr...

objective(s)cutaneous leishmaniasis is a common parasitic disease which is endemic in some parts of the world. in vitro and in vivo studies have shown azithromycin efficacy on some leishmania species. because of structural similarity between clarithromycin and azithromycin and efficacy of clarithromycin against intracellular organisms and due to the absence of previous studies in this respect, ...

background: to clinically characterize the cutaneous leishmaniasis and identify the causative parasite species in mirjaveh, an important geographical region across the border of iran-pakistan at southeast of iran. methods: a number of 116 patients during a year since march 2005 to april 2006, subjected to the study. clinical infor­mation collected and scrapings were taken from cutaneous lesions...

background: leishmaniasis is a complex disease which presents as visceral, cutaneous and mucocutaneous forms. the current treatment options for this infection are very limited and the immunological state of the host appears to play an important role in the efficacy of the treatment. immunostimulation through immune response activating agents such as imiquimod is another rational approach for th...

conclusions this study showed that aqueous allium cepa and ixora brachiata root extracts as natural products could be used as alternative drugs in treatment of leishmaniasis. results among tested plant extracts, ixora brachiata root extracts revealed the best activity against leishmania major promastigotes with ic100 value of 2.5 mg/ml and ic50 value of 0.078 mg/ml. patients and methods the par...

objective(s):cutaneous leishmaniasis is a common and endemic disease in khorasan province in north-east of iran. the pentavalant antimony (sb v) is the mainstay of treatment that has many side effects and resistance to the drug has been reported. the microbicidal effect of ozone was proven in different microorganisms. since there is no study in this respect and to achieve a low cost and effecti...

background: the aim of this study was to assess leishmania infection in sand fly species from areas where leishmaniasis is endemic. this is important for prediction of the risk and expansion of the disease. methods: in this cross-sectional study we used a pcr-based method for detection of leishmania minicircle dna within individual sand flies from orzoieh, a new endemic leishmaniasis focus in s...

background: the purpose of this study was to evaluate antileishmanial effects of asa via no pathway in leishmania major infected balb/c mice. moreover, toxicity and pathological consequences of asa administration were investigated. methods: balb/c mice were infected with l. major and asa was inoculated orally after lesion appearance for its ability to modulate no and to modify leishmania infect...