A 58 year old man was referred to suegery clinic due to dyspnea and left sided chest wall pain for three months duration.during the last 18 months some monomorph disseminated hyperkeratotic skin lesions appeared on his face and trunk.after worlup and evaluation of the patient,he underwent thoracotomy with indication of presence of a mass in the left lung.the operative finding was a huge solid r...

The sign of Leser-Trélat is a rare paraneoplastic phenomenon marked by accelerated onset of multiple seborrheic keratoses. The occurrence of the sign often points towards underlying visceral malignancies which in a majority are adenocarcinomas of the gastrointestinal tract. We report this case of a 65-year-old man who presented with sign of Leser-Trélat and was diagnosed with poorly differentia...

Seborrheic keratosis is the most common benign tumor of epidermis. Rarely develops in perineal area and quite rarely large. For Leser-Trelat syndrome these tumors a marker malignant disease even before symptoms are appeared, as well manifestation paraneoplastic process. In our case report, giant perianal seborrheic keratoma was reason for clinical examination patient stomach cancer detected. As...

593 The Journal of the American Osteopathic Association July 2014 | Vol 114 | No. 7 A 64-year-old man presented to the emergency department with a 1-day history of hematochezia and a 3-month history of melena, during which time he experienced a 20-lb weight loss. Physical examination revealed confluent seborrheic keratoses on the patient’s chest (image). Results of laboratory tests indicated mi...

To cite: Chakradeo K, Narsinghpura K, Ekladious A. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016215316 DESCRIPTION An 87-year-old woman presented with severe iron deficiency anaemia (haemoglobin 57 g/L). She also described a recent increase in the number of pigmented skin lesions on her trunk, which had become mildly pruritic. Her history included a right h...

Leser-Trélat syndrome is characterized by the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. Usually, the sign of Leser-Trélat is associated with adenocarcinoma, most frequently of the colon, breast, or stomach, but also of the lung, kidney, liver, and pancreas. Herein, we present a case that we believe is the first report of the sign of L...

Leser-Trélat sign is a rare cutaneous disorder that manifests with sudden emergence of seborrheic keratoses and increase in their numbers and size within weeks or months. Its concurrence with many types of malignancies, especially adenocarcinoma and lymphoma, has been reported in the literature. In this case report, a patient having Leser-Trélat sign, without any detected malignancy in spite of...

INTRODUCTION The sign of Leser-Trélat is defined by the sudden appearance and rapid increase in number and size of seborrheic keratoses, preceding or revealing a malignancy. Even though this sign remains controversial, it has been described during a wide range of malignancies, including mainly adenocarcinoma of the gastro-intestinal tract or the breast. CASE PRESENTATION We report the case of...

INTRODUCTION Seborrheic keratoses are very common findings in elderly patients. However, a sudden onset and dramatic increase in the number and size of these benign lesions deserves special attention, since this may represent the Leser Trélat sign, a rare paraneoplastic cutaneous syndrome. CASE PRESENTATION A 92-year-old female presented to our clinic with multiple eruptive seborrheic keratos...