Leukemia cutis is a rare entity diagnosed in only 1–3% of Tand B-cell acute lymphoblastic leukemia (ALL).1,2 Aleukemic leukemia cutis (ALC) is an even rarer diagnosis, occurring without leukemic cells in the blood or marrow, often preceding systemic disease.2,3 The Philadelphia chromosome (Ph) is one of the most common chromosomal abnormalities in adult B-ALL patients and is associated with poo...

LC: leukemia cutis T-PLL: T-cell prolymphocytic leukemia L eukemia cutis (LC) is a rare, cutaneous infiltration of neoplastic leukemic cells and correlates strongly to additional sites of extramedullary disease. LC is a nonspecific term for the cutaneous manifestations of many subtypes of leukemia; therefore, the cutaneous morphology and histopathology of LC varies widely. This distinction make...

Cutis verticis gyrata is a long lasting and progressive condition in which there is hypertrophy and folding of the scalp skin. It typically affects the vertex and occipital region; however, it may involve the entire scalp. Classically, it has been divided into primary and secondary forms. Primary has been sub-divided into primary essential and non-essential. Secondary forms are commonly due to ...

Agranular CD4/CD56 hematodermic neoplasm (CD4/CD56 HN), also termed blastic natural killer cell lymphoma, is characterized by a peculiar immunophenotype and high skin tropism. The lineage of origin is not known, and a plasmacytoid dendritic cell derivation has been proposed. CD4/CD56 HN generally is diagnosed by using tumor skin biopsy, with the most important differential diagnosis being myelo...

A 46-year-old man presented with nodular skin lesions, a biopsy specimen of which demonstrated a poorly differentiated malignancy. Touch preparations with histochemical staining and electron microscopy confirmed leukemia cutis. Results from a bone marrow aspirate disclosed focal areas of increased myeloblasts, and cytogenetic analysis revealed an abnormal karyotype as follows 46,XY, t(1;2) (q44...

Iatrogenic calcinosis cutis is a rare disorder that can be due to the intravenous administration of calcium or phosphate-containing infusions such as calcium gluconate or calcium chloride with extravasation. Fortunately, the course of calcinosis cutis is benign in immunocompetent children. The treatment remains supportive therapy. After about 6 months, there is no evidence of tissue calcificati...

Leukemia cutis is a localized or disseminated skin infiltration by leukemic cells. A 64-year-old man was diagnosed with acute myeloid leukemia (AML) complicated by disseminated intravascular coagulation. During the course of treatment with gabexate mesilate, the substance accidentally leaked from the infusion site in his elbow. One month later, a dark red erythema and induration accompanied by ...