a simple, inexpensive and efficient method was used for extraction and determination of fexofenadine and levocetirizine with three–phase hollow fiber liquid-phase microextraction and high-performance liquid chromatography. several parameters influencing the extraction recoveries such as the nature of organic extraction solvent, ph of donor and acceptor phases, stirring rate, extraction time and...

Eosinophils are well known to play essential roles in the development and maintenance of allergic diseases. However, the influence of histamine H1 receptor antagonists on eosinophil functions, especially chemokine production, are not well-defined. Therefore, in the present study, we examined the influence of histamine H1 receptor antagonist on chemokine production by eosinophils through the use...

A Stability indicating reverse phase high performance liquid chromatographic method has been developed for the simultaneous determination of Levocetirizine dihydrochloride and Pseudoephedrine sulfate in pharmaceutical formulation. The mobile phase A consisted of Potassium dihydrogen phosphate Buffer 0.05M and 1-Ocatne sulphonic acid sodium salt 0.25%, pH adjusted to 3.0 with orthophospheric aci...

Histamine H1 antagonists rarely cause drug-induced lung injury (DLI). A woman in her 60s, who had been taking antihistaminic levocetirizine for 2 months, presented with progressive cough and shortness of breath. A chest radiograph showed patchy infiltrations on both lower lung fields. Chest computed tomography findings were consistent with non-specific interstitial pneumonia. Serum markers asso...

People frequently experience whealing and delayed papules from mosquito bites. Various antihistamines have previously been tried for the treatment of this condition. We performed a double-blind, placebo-controlled, cross-over study with levocetirizine 5 mg and matched placebo in 30 adults who were sensitive to mosquito bites. On the third treatment day the subjects received two Aedes aegypti bi...

BACKGROUND AND OBJECTIVE Platelet-activating factor (PAF) is a lipid mediator involved in the pathophysiology of several allergic diseases, for example, in the amplification of mast cell (MC) activation in anaphylaxis. Rupatadine is an antihistamine with a demonstrated anti-PAF effect, although its capacity to inhibit PAF-induced MC degranulation has not been fully evaluated. Objectives: To comp...

Levocetirizine, a second generation non-sedating antihistamine that blocks the H(1) histamine receptor, may exhibit immunoregulatory properties that augment its primary pharmacological mechanism. To investigate this possibility, 13 Kuwaiti seasonal allergic rhinitis (SAR) patients were treated with levocetirizine for four weeks in comparison with a 7-member placebo-treated control group, follow...

OBJECTIVE The Vienna Challenge Chamber (VCC) is an established method for the controlled exposure of patients to specific allergens, used to make valid comparisons between antihistamines. The aim of the significantly more than loratadine at all time two placebo-controlled, randomised studies reported here was to compare the efficacy and safety of levocetirizine 5 mg od and loratadine 10 mg od i...

BACKGROUND There are few published, randomized, double-masked, placebo-controlled, clinical trials of interventions for urticaria in the pediatric population. OBJECTIVE To study the effect of long-term treatment with the H1-antihistamine levocetirizine on urticaria in young atopic children. METHODS In the randomized, double-masked, parallel-group Early Prevention of Asthma in Atopic Childre...