A levonorgestrel-containing intrauterine contraceptive devices are widely used in contemporary gynaecology, primarily as an effective method for contraception and control of menstrual disorders like menorrhagia dysmenorrhea. case report the uterine perforation by levonorgestrel-releasing device (LNG-IUD) a 33-year-old asymptomatic woman after 18-month insertion. On routine cervical smear examin...

The advantages ensuing from the high contraceptive efficacy, positive effect on the parameters of the menstrual cycle as well as other values of the levonorgestrel-releasing intrauterine system may play an important role in women's sexual life. The aim of the study was to evaluate the effect of the levonorgestrel-releasing intrauterine system on the quality of life and sexual functioning of wom...

OBJECTIVE To compare the rate of arterial thromboembolism (ATE) of drospirenone-containing COCs to that of levonorgestrel-containing COCs. DESIGN Population-based cohort study. SETTING United Kingdom's Clinical Practice Research Datalink (CPRD), which contains clinical records for >11 million patients. POPULATION Women aged 16-45 years prescribed a drospirenone- or levonorgestrel-containi...

OBJECTIVE Levonorgestrel-releasing intrauterine system (LNG-IUS) has been shown to be an effective treatment for patients with abnormal uterine bleeding (AUB) in many Western studies. The purpose of study was to examine the effectiveness of LNG-IUS in the treatment of Indian women with AUB. METHODS We conducted a retrospective observational study of 70 women diagnosed with AUB and treated wit...

OBJECTIVE To compare the risk of non-fatal venous thromboembolism in women receiving oral contraceptives containing drospirenone with that in women receiving oral contraceptives containing levonorgestrel. DESIGN Nested case-control and cohort study. SETTING The study was based on information from PharMetrics, a United States based company that collects information on claims paid by managed ...

The levonorgestrel intrauterine system (Mirena((R))) has been developed as a long-acting method of contraception. This medicated device, inserted into the uterus, delivers a small daily dose of a progestin, levonorgestrel, into the uterine cavity. It is one of the most effective methods of contraception and is approved in more than 100 countries for 5 years of use.

OBJECTIVES To assess whether the levonorgestrel intrauterine system could provide a conservative alternative to hysterectomy in the treatment of excessive uterine bleeding. DESIGN Open randomised multicentre study with two parallel groups: a levonorgestrel intrauterine system group and a control group. SETTING Gynaecology departments of three hospitals in Finland. SUBJECTS Fifty six women...

BACKGROUND Progestogens are used clinically for contraception, to control excessive menstrual bleeding, and to prevent estrogen-induced endometrial hyperplasia. A significant problem with progestogen-only methods of contraception is the induction of breakthrough bleeding. METHODS The effects of different progestogens on angiogenesis were examined using two approaches. The mouse sponge angioge...

Three intrauterine devices (IUDs) are available in the United States: the copper T 380A and two levonorgestrel-releasing IUDs, one that releases 20 mcg of levonorgestrel per 24 hours, and one that releases 14 mcg per 24 hours. All are safe and effective methods of contraception that work predominantly by prefertilization mechanisms. The copper T 380A IUD may be placed in nonpregnant women at an...

OBJECTIVE To compare the efficacy and safety of the levonorgestrel-releasing intrauterine system and oral medroxyprogesterone acetate in the treatment of idiopathic heavy menstrual bleeding. METHODS In this multicenter, randomized, controlled study, women aged 18 years or older with heavy menstrual bleeding (menstrual blood loss 80 mL or more per cycle) were randomly assigned to six cycles of...