An 11 year old female presents with a 6-week history of double and blurred vision associated headaches neck swelling. Thyroid function tests demonstrated antibody negative hypothyroidism. In addition, connective tissue disorder screening was negative. The patient commenced on thyroid hormone replacement (levothyroxine).

introduction: some studies indicate changes in the level of thyroid hormones in addicted people. also, there are some reports concerning the modulation of hypothalamus-hypophysis-thyroid axis in the context of morphine addiction. in the present study, the effects of thyroid gland activation via the acute and chronic administration of levothyroxine on morphine withdrawal syndrome were investigat...

BACKGROUND Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before twenty weeks of gestation. It is caused by a variety of genetics and non-genetics factors. Thyroid autoimmunity could associate with pregnancy loss. OBJECTIVE To investigate the effectiveness of Levothyroxine in treatment of RPL in women with high auto-thyroid antibodies. MATERIALS AND ME...

PURPOSE Congenital hypothyroidism (CH) is the most common cause of preventable mental retardation. Recently, the detection of CH cases with eutopic thyroid gland has increased due to neonatal screening programs. In this study, we aimed to identify and evaluate predictive factors that could distinguish between permanent and transient CH in patients with eutopic thyroid gland. METHODS We retros...

A 73-year-old woman was admitted with fatigue, nausea, cold-intolerance, hair-loss, brittle nails, progressive weakness and impressive facial oedema 6 months after starting imatinib (600 mg daily) for metastatic gastrointestinal stromal tumour (GIST, Figure 1) elsewhere. Previously, she had thyroidectomy and I-ablation for follicular thyroid carcinoma. She always had normal thyroid function usi...

Introduction: Trace elements are important for the normal function of thyroid and prevention of its diseases. Normal activities of thyroid including the synthesis of thyroid hormones and regulation of metabolism are dependent on the presence of trace elements. On the other hand, thyroid hormones may also affect the trace element levels. In this study, we investigated the effects of induced hype...

Several haemostatic abnormalities have been reported in thyroid hormone excess. However, the overall effect on coagulation and fibrinolysis is still unclear. We were presented the unique opportunity to further explore the effects of excessive levels of thyroid hormone in the case of a young woman who attempted suicide by auto-intoxication with levothyroxine. Levels of thyroid hormones and param...

BACKGROUND Thyroid hormone replacement is one of the most commonly prescribed and cost effective treatments for a chronic disease. There have been recent changes in community prescribing policies in many areas of the UK that have changed patient access to necessary medications. This study aimed to provide a picture of thyroid hormone usage in the UK and to survey patient opinion about current c...

CONTEXT Patients treated with levothyroxine typically ingest it in a fasting state to prevent food impairing its absorption. The serum thyrotropin concentration is the therapeutic index of levothyroxine action. OBJECTIVE The study objective was to determine the effect of the timing of levothyroxine administration in relationship to food on serum thyrotropin levels. DESIGN Participants were ...

Data from National Health and Nutrition Examination Survey (NHANES 1999-2002) reveals 3.7% prevalence of hypothyroidism in the general population [1]. 10.3 million People or 4.6% of those surveyed reported use of thyroid hormones (levothyroxine, liothyronine, or desiccated thyroid) [1]. Desiccated Thyroid Extract (DTE) of animal origin has been used to treat hypothyroidism since 1892 [2,3]. Sev...