OBJECTIVE Men with congenital adrenal hyperplasia (CAH) have impaired fertility. We aimed to assess fertility outcomes and the importance of hypogonadotropic hypogonadism, testicular failure and the presence of testicular adrenal rest tumours (TART). DESIGN Retrospective analysis of men attending an adult CAH clinic in a tertiary centre. PATIENTS Fifty men with CAH due to 21 hydroxylase def...

The patterns of LH and FSH secretion were measured in 4 experimental groups of Finnish Landrace and Scottish Blackface ewes: long-term (18 months) ovariectomized ewes (Group 1), long-term ovariectomized ewes with an oestradiol implant, which has been shown to produce peripheral levels of approximately 5 pg/ml (Group 2), long-term ovariectomized ewes with an oestradiol implant for 18 months whic...

One hundred anestrous mares (early February) were injected s.c. with implants containing 0, .9, 1.8, 3.6, or 5.4 mg of a GnRH analogue (goserelin acetate) in an attempt to induce ovarian cyclicity. Follicular activity and concentrations of progesterone and LH were determined every 3 d, or daily during estrus. In treated mares that ovulated, the interval to the second ovulation of the season was...

Studies using pharmacological gonadotropin stimulation suggest that ovarian steroidogenesis is abnormal in the polycystic ovary syndrome (PCOS). We assessed ovarian steroid secretion in response to near-physiological gonadotropin stimuli in 12 ovulatory controls and 7 women with PCOS. A gonadotropin-releasing hormone-receptor antagonist (ganirelix, 2 mg sc) was given to block endogenous LH secr...

The plasma LH concentration in ovariectomized lactating rats is low for 14 days postpartum, while the prolactin concentration is high during this period. We examined the effect of the inhibition of increased prolactin secretion with bromocriptine (CB-154) on the LH secretion in lactating rats ovariectomized on day 2 (day 0 = day of parturition). Blood samples were collected through an indwellin...

Then LH (1 + ε)LG, ⇐⇒ (1 + ε)LG − LH 0⇒ (1 + ε)xLGx− xLHx ≥ 0⇒ (1 + ε)|δG(S)| ≥ w(δH(S)). Similarly, if LH (1− ε)LG, we can show that w(δH(S)) ≥ (1− ε)|δG(S)|. We use cut sparsifiers in algorithms that find cuts (sparse cuts, min s-t cuts) in order to replace m in the runtime with O((n log n)/ε2). Of course, this is only useful if we can find the cut sparsifier in the first place in time that’s...

Implants ofprogesterone on the day ofdioestrus II in the hamster induced on the following day an increase in circulating levels of progesterone (6\m=.\0\m=+-\0\m=.\7ng/ml, N = 8; sesame oil controls, <0.5 ng/ml, N = 6) and a decline in serum levels of LH (5\m=.\3\m=+-\0\m=.\4ng/ml; controls 12 \m=+-\2 ng/ml) and oestradiol (10 \m=+-\2 pg/ml ; controls 69 \m=+-\5 pg/ml). The production of andros...

We investigated changes in the peripheral plasma concentrations of ovarian steroids and gonadotropins throughout the estrous cycle of the Microminipig (MMpig), a novel experimental animal model. The mean (± standard error of the mean (SEM)) duration of estrous and the estrous cycle in seven animals was 66.0 ± 5.2 h and 20.6 ± 0.3 days, respectively. A luteinizing hormone (LH) surge was observed...

Synthetic luteinizing hormone-releasing hormone (LH-RH) was given in doses of 11-100 Vg to normal men. Doses of 50 and 100 t±g caused a twoto ten-fold rise in serum LH in all subjects, but in only 40% was the serum follicle-stimulating hormone (FSH) elevated. A significantly higher LH response to LHRH was seen in subjects in whom a rise in serum FSH could be detected. Although there was a wide ...

(1.3) Lku = 0, k = 1,. . . , m. Any function u satisfying all the above equations must also satisfy the equations (1.4) [Lk9 Lh]u = LkLhu LhLku = 0. Thus it is reasonable to assume that the space spanned by the vector fields Lu..., Lm is closed under the bracket operation. Condition A. This condition is satisfied if (1.5) [Lk,IJ = I 4 ^ j where the a^6C°°((7). From (1.2) we obtain [Lk,Lh]u = Lk...