Plasminogen deficiency has emerged as a well-recognized disorder in which reduced levels of plasminogen lead to the development of pseudo membranes on mucosal surfaces, with subsequent end-organ damage of the affected tissue. Ligneous conjunctivitis is the most recognizable, well-documented, and common presentation of the clinical syndromes associated with plasminogen deficiency, although numer...

OBJECTIVE Report the case of a patient with Crohn's disease and ligneous conjunctivitis. METHODS Interventional case report of a 27-year old female patient, with a 4-year history of Crohn's disease, was seen for right eye conjunctival ulcer after resolved chemical trauma. Conjunctival biopsy was performed for histopathology, immunofluorescence microscopy, and immunohistochemistry testing. R...

Objective: Ligneous gingivitis (LG) is an uncommon disease caused by plasminogen deficiency with fibrin deposition, which affects principally the conjunctiva of eyes. A systemic review reported cases and case series was undertaken to evaluate this disease. Methods: Searches detailed databases were performed. The variables demographics, treatment, follow-up, location, histopathological findings,...