نتایج جستجو برای: like fragments

تعداد نتایج: 705432  

Journal: :Biophysica 2023

In the drug design process, a frequent task is decomposition of small molecules into fragments. There exist number approaches and methods to break However, method that allows non-overlapping fragments meaningful in terms medicinal chemistry absent, this work, we present new simple approach for molecules—MedChemFrag. It aims drug-like set rings linkers, which are close perception “fragments” by ...

Journal: :journal of agricultural science and technology 2015
m. pouresmael j. mozafari r. a. khavari-nejad f. najafi f. moradi

drought sensitivity is considered as a major concern for chickpea (c. arietinum) seed production. determination of drought adaptation mechanisms is an essential constituent of this crop breeding programs. with this purpose, the present research was conducted to distinguish the molecular basis of chickpea drought tolerance using cdna-aflp approach. the expression profile was compared between dro...

2012
Andrew T. N. Tebbenkamp Keith W. Crosby Zoe B. Siemienski Hilda H. Brown Todd E. Golde David R. Borchelt

BACKGROUND N-terminal fragments of mutant huntingtin (htt) that terminate between residues 90-115, termed cleavage product A or 1 (cp-A/1), form intracellular and intranuclear inclusion bodies in the brains of patients with Huntington's disease (HD). These fragments appear to be proteolytic products of the full-length protein. Here, we use an HEK293 cell culture model to investigate huntingtin ...

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