background and objective: evaluation of degenerative changes of motoneurons and their related synapses can be useful in understanding the mechanisms of neurodegenerative diseases and their potential treatment. the present electron microscopic and immunohistochemical study investigates the axotomy-induced changes of adult spinal motoneurons up to 3 months following sciatic nerve transection. mat...

cell replacement therapy has provided the basis for future clinical applications to treat central nervous system injuries fallowing by car accidents. induced functional neurons are an option for replacing the lost neurons. the ability to monitor changes in membrane potential is a useful tool for studying neuronal function, but there are only limited options available at present. here, investiga...

Synaptic plasticity allows cortical circuits to learn new tasks and adapt changing environments. How do use acquire functions such as decision-making or working memory? Neurons are connected in complex ways, forming recurrent neural networks, learning modifies the strength of their connections. Moreover, neurons communicate emitting brief discrete electric signals. Here we describe how train ne...

The resistive switching induced in Mott materials by a strong applied voltage allows for artificial spiking neurons with great potential. However, controlling the collapse is challenge, as we lack physical understanding of phenomenon. Here numerical simulations and experiments reveal how thermal electronic effects jointly contribute to intrinsically stochastic, more surprisingly it Poissonian p...