Lindane, an organochlorine pesticide, has been widely used in public health and agriculture in several countries including India. Lindane has long been associated with pollution due to its long persistence and quick accumulation in fatty tissues. It is considered a possible carcinogen, mutagen, teratogen, immunotoxin, and neurotoxin in mammals. However, data on toxicity of lindane to fish is in...

Treatment for scabies is usually initiated by general practitioners; most consider lindane (gamma benzene hexachloride) the treatment of choice. Lindane is also widely used as an agricultural and industrial pesticide, and as a result the toxic profile of this insecticide is well understood. Evidence is accumulating that lindane can be toxic to the central nervous system and may be associated wi...

Background: Scabies is one of the health care problems in our community and is an endemic problem at any time. Its current therapy in Iran is lindane 1% lotion, which is deleted from market in many countries because of multiple side effects and better alternatives. The aim of this study was to evaluate the efficacy and side effects of lindane in patients with scabies and to replace lindane with...

The toxic effects of Lindane (γ-BHC) on Microcystis aeruginosa were studied under lab culture conditions. Total protein levels, as well malondialdehyde (MDA) levels and superoxide dismutase (SOD) enzyme activity, in algal cells, determined after exposure to different concentrations Lindane. bioaccumulation Lindane, the influence pH dissolved organic matter (DOM) effects, was also evaluated cell...

Lindane, a chlorinated hydrocarbon pesticide, was previously shown to enhance the nighttime rise in pineal N-acetyltransferase (NAT) activity and melatonin as well as serum melatonin levels. The purpose of the present study was to test whether lindane acts on the pineal gland by means of a beta-adrenergic receptor mechanism. Whereas lindane (total dose 17.8 mg/kg b.wt. over 6 days) by itself si...

The feeding response of juvenile amphipod Gammarus pulex (L.) was investigated following exposure to freshwater pollutants. The method employed is nondestructive, provides a rapid indication of the status of groups of individuals, and is based on a time-response analysis of the consumption of the eggs of Artemia salina and the determination of median feeding times or FT50s. The feeding activity...

Background: Scabies is a common skin disease and a public health problem. The topical antiscabietics have a poor compliance. The aim of this study was to compare the efficacy of oral Ivermectin with topical Lindane solution in the treatment of scabies. Methods: This was a prospective comparative open study. Fifty seven patients were randomized in two groups. One group (32 patients) received 200...

As part of a project funded by the European Commission (EC) for the development and evaluation of multiresidue methods for analysis of drinking and related waters, 15 European laboratories evaluated a method using styrene-divinylbenzene co-polymer solid-phase extraction followed by gas chromatography/mass spectrometry. The main aim of the study was to evaluate whether the method meets the requi...

The present study was designed to explore the role of gap junctions in follicle-stimulating hormone (FSH) and transforming growth factor beta1 (TGF beta1)-stimulated steroidogenesis in ovarian granulosa cells of gonadotropin-primed immature rats. There were three specific aims. First, we investigated the effect of FSH and TGF beta1 as well as lindane (a general gap junction blocker) on the leve...

DDT and lindane are highly toxic organochlorine pesticides and posing adverse effects on the environment and public health due to their frequent usage in developing countries. ABCC4/MRP4 is an organic anion transporter that mediates cellular efflux of a wide range of exogenous and endogenous compounds such as cyclic nucleotides and anti-cancer drugs; however, it remains unclear whether ABCC4 an...