The sectional stresses (M, N) in a gallery lining are computed comparatively numerical by FEM taking into account the interaction underground structure – surrounding ground and analytical by Protodiakonov method. The last method is based on coincidence arch born in ground over gallery. Comprehensive analyses allow to settle the domain in which Protodiakonov method can be applied as well as the ...

Hyperstatic Reaction Method (HRM) is a simple but effective method with attractive features in calculating internal forces and deformations of the tunnel lining. The superior ability HRM under static conditions inspires further development this for seismic design. This paper implements an improved estimating seismic-induced lining quasi-static condition. To end, modification parameter (a) appro...

The ER-resident regulatory protein STIM1 triggers store-operated Ca(2+) entry by direct interaction with the plasma membrane Ca(2+) channel ORAI1. The mechanism of channel gating remains undefined. Here we establish that STIM1 gates the purified recombinant ORAI1 channel in vitro, and use Tb(3+) luminescence and, separately, disulfide crosslinking to probe movements of the pore-lining helices. ...

The shallow tunnelling method (STM) is usually used to construct tunnels buried in soft ground. It consists of primary lining and secondary (tunnel). In the seismic design STM tunnels, it assumed that (tunnel) resistant all effects. However, soil–primary–secondary system may generate complex interaction phenomena during ground shaking. Compared with case where not considered, existence alters r...

Osteoimmunolgy involves the interaction of the immune system with skeletal elements. This interaction can lead to the formation of osseous lesions. To investigate how the acquired immune response could contribute to osteolytic lesions, we injected the periodontal pathogen Porphyromonas gingivalis adjacent to calvarial bone with or without prior immunization against the bacterium. Activation of ...