background: hippocampal damages, which are accompanied by inflammation, are among the main causes of epilepsy acquisition. we previously reported that chronic intracerebroventricular (i.c.v.) injection of lipopolysaccharide (lps) modulates epileptogenesis in rats. there is a network of gap junction channels in the hippocampus that contribute to epileptogenesis. gap junction channels are formed ...

The aim of this study was to evaluate for the first time anti-inflammatory effects chestnut (Castanea sativa) and Eucalyptus (Eucalyptus occidentalis) honeys collected in Italy on murine RAW 264.7 macrophages stressed with bacterial endotoxin lipopolysaccharide (LPS). Pre-treatment two markedly decreased apoptosis stimulated wound healing LPS, where they also reduced intracellular levels ROS ni...

Until now, the physiological effects of Soroseris hirsuta were primarily unknown. Here we have evaluated anti-inflammatory and antioxidant extract (SHE) on lipopolysaccharide (LPS)-activated murine macrophages RAW 264.7 cells. SHE inhibited nitric oxide expression inducible synthase in cells treated with LPS. Moreover, suppressed LPS-induced phosphorylation IκB kinase, inhibitor kappa B, p65, p...

Abstract Background and Aims Cellular fatty acid metabolism was supposed to be tightly associated with immune responses. Pyroptosis is a form of programmed cell death dependent on the NLRP3 inflammasome activation. Previous studies have revealed that acyl-CoA synthetase 2 (ACSS2) promoted synthesis under metabolic stress. However, whether ACSS2-mediated can regulate pyroptosis inflammatory resp...

Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...

background: activation of inflammatory cells can cause more chemicals induced-hepatotoxicity. aflatoxin b1 (afb1) is a fungal toxin that induces acute hepatotoxicity in humans and animals. this study was conducted to examine the effect of co-exposure lps and various aflatoxin b1 doses on the damage hepatic parameters in isolated perfused rat liver. methods: thirty-two male wistar rats (250-300g...

ABSTRACT The objective of the present study was to evaluate effect lipopolysaccharide (LPS) administration on activation and apoptosis primordial follicles. There no difference in total number follicles as well different types Furthermore, LPS challenge didn’t modulate expression genes related with ovarian reserve (HAM), oocyte survival (Survivin), rate (Pten, KIT, KITL1, KITL2, AKT1, SIRT1), f...

Background and Objective: Depression is a common disorder, especially in developed countries. Functional changes of cholinesterase are involved in pathogenesis of some brain disorders. Until now, exact association of these changes with depression has not been determined. This study was conducted to evaluate the changes of serum cholinesterase in lipopolysaccharide (LPS)-induced model of depress...

The immune system can influence social motivation with potentially dire consequences for group-housed production animals, such as pigs. aim of this study was to test the effect a controlled activation in pigs, through an injection lipopolysaccharide ( LPS ) and intervention ketoprofen on centrality parameters at individual level. In addition, we wanted time relative general network order get be...