results a significant increase in blood abca1 (ex group p < 0.002, t = - 9.876) and apo a-i (ex group p < 0.05, t = 2.76) gene expression was shown following the 12 weeks of training. plasma high-density lipoprotein-cholesterol (hdl-c) concentration increased (p < 0.001, t = 4.90 respectively) while plasma low-density lipoprotein-cholesterol (ldl-c) concentration decreased (p < 0.001, t = 4.27)...

coronary artery disease (cad) is a leading cause of morbidity and mortality in most countries. this disease is directly associated with increased low–density lipoprotein cholesterol (ldl-c) and is conversely associated with high–density lipoprotein cholesterol (hdl-c) concentrations. abca1 is the main exporter of phospholipid and cholesterol from cells to lipid-free or minimum lipid apolipoprot...

The CYP2A6 gene, which codes the enzyme, has known to have ahigh polymorphism. This polymorphism could decrease, increase, or eliminate enzyme activity. CYP2A6*4 , an inactive allele, decreased One of enzyme-specific substrates is nicotine. allele decrease nicotine metabolism that causes high levels in blood. In addition, it caused increasing Low-Density Lipoprotein Cholesterol (LDL-C) by expan...

OBJECTIVE To better understand the role of lecithin:cholesterol acyltransferase (LCAT) in lipoprotein metabolism through the genetic and biochemical characterization of families carrying mutations in the LCAT gene. METHODS AND RESULTS Thirteen families carrying 17 different mutations in the LCAT gene were identified by Lipid Clinics and Departments of Nephrology throughout Italy. DNA analysis...