نتایج جستجو برای: liposome nanoparticle nanotherapy

تعداد نتایج: 38036  

2016
Marco Giardiello Neill J Liptrott Tom O McDonald Darren Moss Marco Siccardi Phil Martin Darren Smith Rohan Gurjar Steve P Rannard Andrew Owen

Considerable scope exists to vary the physical and chemical properties of nanoparticles, with subsequent impact on biological interactions; however, no accelerated process to access large nanoparticle material space is currently available, hampering the development of new nanomedicines. In particular, no clinically available nanotherapies exist for HIV populations and conventional paediatric HI...

2014
Raphaël Duivenvoorden Jun Tang David P. Cormode Aneta J. Mieszawska David Izquierdo-Garcia Canturk Ozcan Maarten J. Otten Neeha Zaidi Mark E. Lobatto Sarian M. van Rijs Bram Priem Emma L. Kuan Catherine Martel Bernd Hewing Hendrik Sager Matthias Nahrendorf Gwendalyn J. Randolph Erik S.G. Stroes Valentin Fuster Edward A. Fisher Zahi A. Fayad Willem J.M. Mulder

Inflammation is a key feature of atherosclerosis and a target for therapy. Statins have potent anti-inflammatory properties but these cannot be fully exploited with oral statin therapy due to low systemic bioavailability. Here we present an injectable reconstituted high-density lipoprotein (rHDL) nanoparticle carrier vehicle that delivers statins to atherosclerotic plaques. We demonstrate the a...

2016
Victor U. Weiss Carlos Urey Andreas Gondikas Monika Golesne Gernot Friedbacher Frank von der Kammer Thilo Hofmann Roland Andersson György Marko-Varga Martina Marchetti-Deschmann Günter Allmaier

Liposomes are biodegradable nanoparticle vesicles consisting of a lipid bilayer encapsulating an aqueous core. Entrapped cargo material is shielded from the extra-vesicular medium and sustained release of encapsulated material can be achieved. However, application of liposomes as nano-carriers demands their characterization concerning size and size distribution, particle-number concentration, o...

Journal: :ACS nano 2014
Cécile Bonnaud Christophe A Monnier Davide Demurtas Corinne Jud Dimitri Vanhecke Xavier Montet Ruud Hovius Marco Lattuada Barbara Rothen-Rutishauser Alke Petri-Fink

A major contemporary concern in developing effective liposome-nanoparticle hybrids is the present inclusion size limitation of nanoparticles between vesicle bilayers, which is considered to be around 6.5 nm in diameter. In this article, we present experimental observations backed by theoretical considerations which show that greater structures can be incorporated within vesicle membranes by pro...

Journal: :Chemical communications 2016
Samit Guha Gillian Karen Shaw Trevor M Mitcham Richard R Bouchard Bradley D Smith

Absorption of 808 nm laser light by liposomes containing a pH sensitive, near-infrared croconaine rotaxane dye increases dramatically in weak acid. A stealth liposome composition permits acid activated, photothermal heating and also acts as an effective nanoparticle probe for ratiometric photoacoustic imaging of acidic pH in deep sample locations, including a living mouse.

2017
Agus Haryono Korrie Salsabila Witta Kartika Restu Sri Budi Harmami Dodi Safari

BACKGROUND We investigate the immunogenic properties of chitosan and liposome nanoparticles as adjuvant codelivery against a commercial pneumococcal conjugate vaccine (PCV) in an animal model. METHODS The chitosan and liposome nanoparticles were prepared by ionic gelation and dry methods, respectively. The PCV immunization was performed intradermally in the presence of adjuvants and booster i...

Journal: :Materials 2021

The scientific community has made great efforts in advancing magnetic hyperthermia for the last two decades after going through a sizeable research lapse from its establishment. All progress various topics ranging nanoparticle synthesis to biocompatibilization and vivo testing have been seeking push forefront towards some new clinical trials. As many, they did not go at expected pace. Today, fr...

2017
Leigh P Brody Meliz Sahuri-Arisoylu James R Parkinson Harry G Parkes Po Wah So Nabil Hajji E Louise Thomas Gary S Frost Andrew D Miller Jimmy D Bell

Metabolic reengineering using nanoparticle delivery represents an innovative therapeutic approach to normalizing the deregulation of cellular metabolism underlying many diseases, including cancer. Here, we demonstrated a unique and novel application to the treatment of malignancy using a short-chain fatty acid (SCFA)-encapsulated lipid-based delivery system - liposome-encapsulated acetate nanop...

2015

Submit Manuscript | http://medcraveonline.com and therapy of cancer which is also called theranostic nanoparticle could be a highly demanded medicine in the future to improve personalized cancer disease management [2]. Several organic and inorganic nanoparticles have been in the race to design the best theranostic nanoparticle that can efficiently target the tumor site without damaging the heal...

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