The conventional Pap test is highly effective for screening of cervical cancer and its precursors but has a false negative rate due to either sampling, preparation or screening. New technologies, such as liquid-based Paps, automated screening devices and high-risk (HR) HPV testing by molecular methods, have been introduced to increase the detection of cervical disease. Two liquid-based technolo...

Dear Dr. Bedrossian: Conventional smears are tedious and time-consuming to screen due to nonuniform slide preparation and fixation. Features usually associated with conventional smears, such as, thick, overlapping cellular areas, obscuring inflammation, and blood and air-drying artifact result in poor cellular and nuclear preservation. Liquid-based preparations (LBP) are increasingly being used...

This workshop is composed of 25 cases from an ongoing local audit selected to demonstrate factors in the screening history that may be relevant to invasive cancer not having been prevented. False positive and false negative cytology slides are included, but the emphasis is placed on multiple factors that are often involved in these cases. Conventional smears and liquid-based preparations (ThinP...

BACKGROUND AND OBJECTIVE Cytologic screening of asymptomatic high risk individuals can detect curable esophageal carcinomas and has been used for several decades. However, the sensitivity of such screening is relatively low, which limits its wide use and development. This study was to investigate the utility of liquid-based cytology in esophageal carcinoma screening. METHODS A mass screening ...

PURPOSE To determine if the presence of observers affects muscular strength performance in college-age males and females. METHODS Twenty-five women and 24 men participated in the study. Two counter-balanced trials were performed in which participants completed 1-RM tests in bench press and leg press. During one trial, two members of the opposite gender observed the 1-RM tests. During the othe...

BACKGROUND Historically there has been a wide variation in the proportion of inadequate smears between general practices. Cervical screening in the UK is undergoing a fundamental change by moving from conventional to liquid based cytology (LBC). The main driver for this change has been a predicted reduction in the proportions of inadequate samples. This study investigates the effect of LBC on t...

OBJECTIVES To predict the incremental lifetime effects, costs, and cost effectiveness of using human papillomavirus testing to triage women with borderline or mildly dyskaryotic cervical smear results for immediate colposcopy. DESIGN Modelling study. SETTING Three centres participating in NHS pilot studies, United Kingdom. Population Women aged 25-64 with borderline or mildly dyskaryotic ce...

CONTEXT Every year approximately 2 million US women are diagnosed as having a cervical cytological result of atypical squamous cells of undetermined significance (ASC-US). OBJECTIVE To determine the most efficient and cost-effective management strategy for women in the United States diagnosed as having ASC-US. DESIGN AND SETTING Cost-effectiveness analysis of data from clinical trials, pros...